The aromatase gene (CYP19A1) variants and circulating hepatocyte growth factor in postmenopausal women

Jennifer H. Lin, Marc J. Gunter, JoAnn E. Manson, Kathryn M. Rexrode, Nancy R. Cook, Peter Kraft, Barbara B. Cochrane, Rowan T. Chlebowski, Gloria Y F Ho, Shumin M. Zhang

Research output: Contribution to journalArticle

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Abstract

Background: Estrogen and androgen have been linked to the regulation of circulating hepatocyte growth factor (HGF), an adipose tissue-derived cytokine. It is possible that the CYP19A1 gene which alters sex hormones production may influence HGF levels. We examined the association between the CYP19A1 gene variants and plasma HGF concentrations. Design: We evaluated 45 common and putative functional variants of CYP19A1 and circulating levels of HGF among 260 postmenopausal women who later developed colorectal cancer from the Women's Health Initiative Observational Cohort. As the distribution of HGF levels was highly skewed, we transformed HGF concentrations for all women into a log-, ranked-, or normal score-scale value. Multiple linear regression with adjustment for age was used to evaluate the associations. Results: We observed an association between the rs7172156, rs1008805, rs6493494, rs749292, and rs11636639 variants and HGF levels in ranked and normal score scales (corrected p values ≤0.02), although the association of these 5 SNPs with log-scale HGF was not significant (corrected p values ≥0.16). The associations remained unchanged after additional adjustment for hormone therapy use and estradiol levels. These 5 SNPs, which were in linkage disequilibrium (pairwise D′≥97%, r2≥56%), constituted a block with 2 common haplotypes accounting for 82% frequency. The most common haplotype, TCCCA, was associated with lower ranked- or normal score-transformed HGF levels (corrected p values ≤0.001), whereas the second most common haplotype, CTTCA, was associated with higher ranked- or normal score-transformed HGF levels (corrected p values ≤0.02). Conclusion: Our findings of a potential association between the CYP19A1 variants and circulating HGF levels warrant confirmation in studies with larger sample size.

Original languageEnglish (US)
Article numbere42079
JournalPLoS One
Volume7
Issue number7
DOIs
StatePublished - Jul 25 2012

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hepatocyte growth factor
Aromatase
Hepatocyte Growth Factor
Genes
genes
Haplotypes
haplotypes
Single Nucleotide Polymorphism
aromatase
women's health
sex hormones
Linkage Disequilibrium
Gonadal Steroid Hormones
Women's Health
linkage disequilibrium
androgens
colorectal neoplasms
Linear regression
Sample Size
Androgens

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Lin, J. H., Gunter, M. J., Manson, J. E., Rexrode, K. M., Cook, N. R., Kraft, P., ... Zhang, S. M. (2012). The aromatase gene (CYP19A1) variants and circulating hepatocyte growth factor in postmenopausal women. PLoS One, 7(7), [e42079]. https://doi.org/10.1371/journal.pone.0042079

The aromatase gene (CYP19A1) variants and circulating hepatocyte growth factor in postmenopausal women. / Lin, Jennifer H.; Gunter, Marc J.; Manson, JoAnn E.; Rexrode, Kathryn M.; Cook, Nancy R.; Kraft, Peter; Cochrane, Barbara B.; Chlebowski, Rowan T.; Ho, Gloria Y F; Zhang, Shumin M.

In: PLoS One, Vol. 7, No. 7, e42079, 25.07.2012.

Research output: Contribution to journalArticle

Lin, JH, Gunter, MJ, Manson, JE, Rexrode, KM, Cook, NR, Kraft, P, Cochrane, BB, Chlebowski, RT, Ho, GYF & Zhang, SM 2012, 'The aromatase gene (CYP19A1) variants and circulating hepatocyte growth factor in postmenopausal women', PLoS One, vol. 7, no. 7, e42079. https://doi.org/10.1371/journal.pone.0042079
Lin, Jennifer H. ; Gunter, Marc J. ; Manson, JoAnn E. ; Rexrode, Kathryn M. ; Cook, Nancy R. ; Kraft, Peter ; Cochrane, Barbara B. ; Chlebowski, Rowan T. ; Ho, Gloria Y F ; Zhang, Shumin M. / The aromatase gene (CYP19A1) variants and circulating hepatocyte growth factor in postmenopausal women. In: PLoS One. 2012 ; Vol. 7, No. 7.
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abstract = "Background: Estrogen and androgen have been linked to the regulation of circulating hepatocyte growth factor (HGF), an adipose tissue-derived cytokine. It is possible that the CYP19A1 gene which alters sex hormones production may influence HGF levels. We examined the association between the CYP19A1 gene variants and plasma HGF concentrations. Design: We evaluated 45 common and putative functional variants of CYP19A1 and circulating levels of HGF among 260 postmenopausal women who later developed colorectal cancer from the Women's Health Initiative Observational Cohort. As the distribution of HGF levels was highly skewed, we transformed HGF concentrations for all women into a log-, ranked-, or normal score-scale value. Multiple linear regression with adjustment for age was used to evaluate the associations. Results: We observed an association between the rs7172156, rs1008805, rs6493494, rs749292, and rs11636639 variants and HGF levels in ranked and normal score scales (corrected p values ≤0.02), although the association of these 5 SNPs with log-scale HGF was not significant (corrected p values ≥0.16). The associations remained unchanged after additional adjustment for hormone therapy use and estradiol levels. These 5 SNPs, which were in linkage disequilibrium (pairwise D′≥97{\%}, r2≥56{\%}), constituted a block with 2 common haplotypes accounting for 82{\%} frequency. The most common haplotype, TCCCA, was associated with lower ranked- or normal score-transformed HGF levels (corrected p values ≤0.001), whereas the second most common haplotype, CTTCA, was associated with higher ranked- or normal score-transformed HGF levels (corrected p values ≤0.02). Conclusion: Our findings of a potential association between the CYP19A1 variants and circulating HGF levels warrant confirmation in studies with larger sample size.",
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AU - Cook, Nancy R.

AU - Kraft, Peter

AU - Cochrane, Barbara B.

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AB - Background: Estrogen and androgen have been linked to the regulation of circulating hepatocyte growth factor (HGF), an adipose tissue-derived cytokine. It is possible that the CYP19A1 gene which alters sex hormones production may influence HGF levels. We examined the association between the CYP19A1 gene variants and plasma HGF concentrations. Design: We evaluated 45 common and putative functional variants of CYP19A1 and circulating levels of HGF among 260 postmenopausal women who later developed colorectal cancer from the Women's Health Initiative Observational Cohort. As the distribution of HGF levels was highly skewed, we transformed HGF concentrations for all women into a log-, ranked-, or normal score-scale value. Multiple linear regression with adjustment for age was used to evaluate the associations. Results: We observed an association between the rs7172156, rs1008805, rs6493494, rs749292, and rs11636639 variants and HGF levels in ranked and normal score scales (corrected p values ≤0.02), although the association of these 5 SNPs with log-scale HGF was not significant (corrected p values ≥0.16). The associations remained unchanged after additional adjustment for hormone therapy use and estradiol levels. These 5 SNPs, which were in linkage disequilibrium (pairwise D′≥97%, r2≥56%), constituted a block with 2 common haplotypes accounting for 82% frequency. The most common haplotype, TCCCA, was associated with lower ranked- or normal score-transformed HGF levels (corrected p values ≤0.001), whereas the second most common haplotype, CTTCA, was associated with higher ranked- or normal score-transformed HGF levels (corrected p values ≤0.02). Conclusion: Our findings of a potential association between the CYP19A1 variants and circulating HGF levels warrant confirmation in studies with larger sample size.

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