The antigen processing and presentation machinery in lymphatic endothelial cells

Laura Santambrogio, Stella J. Berendam, Victor H. Engelhard

Research output: Contribution to journalReview article

3 Scopus citations


Until a few years ago, lymphatic vessels and lymphatic endothelial cells (LEC) were viewed as part of a passive conduit for lymph and immune cells to reach lymph nodes (LN). However, recent work has shown that LEC are active immunological players whose interaction with dendritic cells and T cells is of important immunomodulatory relevance. While the immunological interaction between LEC and other immune cells has taken a center stage, molecular analysis of LEC antigen processing and presentation machinery is still lagging. Herein we review the current knowledge of LEC MHC I and MHC II antigen processing and presentation pathways, Including the role of LEC in antigen phagocytosis, classical, and non-classical MHC II presentation, proteasome processing and MHC I presentation, and cross-presentation. The ultimate goal is to provide an overview of the LEC antigen processing and presentation machinery that constitutes the molecular basis for their role in MHC I and MHC II-restricted immune responses.

Original languageEnglish (US)
Article number1033
JournalFrontiers in immunology
Issue numberMAY
StatePublished - Jan 1 2019



  • Antigen processing and presentation
  • Lymph
  • Lymphatic endothelial cells
  • MHC class I
  • MHC class II

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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