The Antifolates

Michele Visentin, Rongbao Zhao, I. David Goldman

Research output: Contribution to journalReview article

104 Scopus citations

Abstract

This article focuses on the cellular, biochemical, and molecular pharmacology of antifolates and how a basic understanding of the mechanism of action of methotrexate, its cytotoxic determinants, mechanisms of resistance, and transport into and out of cells has led to the development of a new generation of antifolates, a process that continues in the laboratory and in the clinics. New approaches to folate-based cancer chemotherapy are described based on the targeted delivery of drugs to malignant cells.

Original languageEnglish (US)
Pages (from-to)629-648
Number of pages20
JournalHematology/Oncology Clinics of North America
Volume26
Issue number3
DOIs
StatePublished - Jun 1 2012

Keywords

  • Antifolates
  • Folate receptor-mediated endocytosis
  • Folate receptors
  • Methotrexate
  • Pemetrexed
  • Pralatrexate
  • Proton-coupled folate transporter (PCFT)
  • Reduced folate carrier (RFC)

ASJC Scopus subject areas

  • Hematology
  • Oncology

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