The analysis of multivariate interval-censored survival data

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32 Scopus citations

Abstract

This paper considers a marginal approach for the analysis of the effect of covariates on multivariate interval-censored survival data. Interval censoring of multivariate events can occur when the events are not directly observable but are detected by periodically performing clinical examinations or laboratory tests. The method assumes the marginal distribution for each event is based on a discrete analogue of the proportional hazards model for interval-censored data. A robust estimator for the covariance matrix is developed that accounts for the correlation between events. A simulation study comparing the performance of this method and a midpoint imputation approach indicates the parameter estimates from the proposed method are less biased. Furthermore, even when the events are only modestly correlated, ignoring the correlation can result in erroneous variance estimators. The method is illustrated using data from an ongoing clinical trial involving subjects with systemic lupus erythematosus.

Original languageEnglish (US)
Pages (from-to)3715-3726
Number of pages12
JournalStatistics in Medicine
Volume21
Issue number23
DOIs
StatePublished - Dec 15 2002
Externally publishedYes

Keywords

  • Interval censoring
  • Multivariate survival data
  • Recurrent events
  • Robust inference

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability

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