The analgesic effects that underlie patient satisfaction with treatment

Mark P. Jensen, Tito Mendoza, David B. Hanna, Connie Chen, Charles S. Cleeland

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Patient satisfaction and global ratings of study medications are increasingly used as secondary outcome measures in pain clinical trials. However, little is known about the factors that underlie and contribute to these ratings. 191 patients who participated in a randomized trial of parenteral parecoxib sodium followed by oral valdecoxib for pain following laparoscopic cholecystectomy versus standard care rated their satisfaction with the overall performance of the study medications (postoperative days 1 and 7) and also provided global evaluation of the analgesics on postoperative day 7. Analyses indicated that treatment regimen, age, worst pain experienced, pain interference with functioning, morphine equivalent dose taken, and number of opioid-related symptoms (e.g. nausea, fatigue) were all associated with satisfaction with the overall performance of the study medications at day 1. Controlling for all of the predictors, pain interference and morphine equivalent dose use made independent contributions to the prediction of the day 1 global rating. These results were replicated in the prediction of day 7 ratings, except that at day 7, treatment regimen also made a significant independent contribution to the prediction of satisfaction. These findings indicate that the study participants considered more than one factor when estimating their satisfaction with the study medications, and that the changes produced by the treatment (e.g. decreased pain, opioid-related symptoms) mediated, in part, the effects of treatment on treatment satisfaction.

Original languageEnglish (US)
Pages (from-to)480-487
Number of pages8
JournalPain
Volume110
Issue number1-2
DOIs
StatePublished - Jul 2004
Externally publishedYes

Fingerprint

Patient Satisfaction
Analgesics
Pain
Morphine
Opioid Analgesics
Therapeutics
Laparoscopic Cholecystectomy
Nausea
Fatigue
Outcome Assessment (Health Care)
Clinical Trials

Keywords

  • Assessment
  • Global assessment
  • Outcomes assessment
  • Pain clinical trials
  • Satisfaction

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

The analgesic effects that underlie patient satisfaction with treatment. / Jensen, Mark P.; Mendoza, Tito; Hanna, David B.; Chen, Connie; Cleeland, Charles S.

In: Pain, Vol. 110, No. 1-2, 07.2004, p. 480-487.

Research output: Contribution to journalArticle

Jensen, MP, Mendoza, T, Hanna, DB, Chen, C & Cleeland, CS 2004, 'The analgesic effects that underlie patient satisfaction with treatment', Pain, vol. 110, no. 1-2, pp. 480-487. https://doi.org/10.1016/j.pain.2004.04.036
Jensen, Mark P. ; Mendoza, Tito ; Hanna, David B. ; Chen, Connie ; Cleeland, Charles S. / The analgesic effects that underlie patient satisfaction with treatment. In: Pain. 2004 ; Vol. 110, No. 1-2. pp. 480-487.
@article{a260033fbb4340cb9ae91948ada906ea,
title = "The analgesic effects that underlie patient satisfaction with treatment",
abstract = "Patient satisfaction and global ratings of study medications are increasingly used as secondary outcome measures in pain clinical trials. However, little is known about the factors that underlie and contribute to these ratings. 191 patients who participated in a randomized trial of parenteral parecoxib sodium followed by oral valdecoxib for pain following laparoscopic cholecystectomy versus standard care rated their satisfaction with the overall performance of the study medications (postoperative days 1 and 7) and also provided global evaluation of the analgesics on postoperative day 7. Analyses indicated that treatment regimen, age, worst pain experienced, pain interference with functioning, morphine equivalent dose taken, and number of opioid-related symptoms (e.g. nausea, fatigue) were all associated with satisfaction with the overall performance of the study medications at day 1. Controlling for all of the predictors, pain interference and morphine equivalent dose use made independent contributions to the prediction of the day 1 global rating. These results were replicated in the prediction of day 7 ratings, except that at day 7, treatment regimen also made a significant independent contribution to the prediction of satisfaction. These findings indicate that the study participants considered more than one factor when estimating their satisfaction with the study medications, and that the changes produced by the treatment (e.g. decreased pain, opioid-related symptoms) mediated, in part, the effects of treatment on treatment satisfaction.",
keywords = "Assessment, Global assessment, Outcomes assessment, Pain clinical trials, Satisfaction",
author = "Jensen, {Mark P.} and Tito Mendoza and Hanna, {David B.} and Connie Chen and Cleeland, {Charles S.}",
year = "2004",
month = "7",
doi = "10.1016/j.pain.2004.04.036",
language = "English (US)",
volume = "110",
pages = "480--487",
journal = "Pain",
issn = "0304-3959",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - The analgesic effects that underlie patient satisfaction with treatment

AU - Jensen, Mark P.

AU - Mendoza, Tito

AU - Hanna, David B.

AU - Chen, Connie

AU - Cleeland, Charles S.

PY - 2004/7

Y1 - 2004/7

N2 - Patient satisfaction and global ratings of study medications are increasingly used as secondary outcome measures in pain clinical trials. However, little is known about the factors that underlie and contribute to these ratings. 191 patients who participated in a randomized trial of parenteral parecoxib sodium followed by oral valdecoxib for pain following laparoscopic cholecystectomy versus standard care rated their satisfaction with the overall performance of the study medications (postoperative days 1 and 7) and also provided global evaluation of the analgesics on postoperative day 7. Analyses indicated that treatment regimen, age, worst pain experienced, pain interference with functioning, morphine equivalent dose taken, and number of opioid-related symptoms (e.g. nausea, fatigue) were all associated with satisfaction with the overall performance of the study medications at day 1. Controlling for all of the predictors, pain interference and morphine equivalent dose use made independent contributions to the prediction of the day 1 global rating. These results were replicated in the prediction of day 7 ratings, except that at day 7, treatment regimen also made a significant independent contribution to the prediction of satisfaction. These findings indicate that the study participants considered more than one factor when estimating their satisfaction with the study medications, and that the changes produced by the treatment (e.g. decreased pain, opioid-related symptoms) mediated, in part, the effects of treatment on treatment satisfaction.

AB - Patient satisfaction and global ratings of study medications are increasingly used as secondary outcome measures in pain clinical trials. However, little is known about the factors that underlie and contribute to these ratings. 191 patients who participated in a randomized trial of parenteral parecoxib sodium followed by oral valdecoxib for pain following laparoscopic cholecystectomy versus standard care rated their satisfaction with the overall performance of the study medications (postoperative days 1 and 7) and also provided global evaluation of the analgesics on postoperative day 7. Analyses indicated that treatment regimen, age, worst pain experienced, pain interference with functioning, morphine equivalent dose taken, and number of opioid-related symptoms (e.g. nausea, fatigue) were all associated with satisfaction with the overall performance of the study medications at day 1. Controlling for all of the predictors, pain interference and morphine equivalent dose use made independent contributions to the prediction of the day 1 global rating. These results were replicated in the prediction of day 7 ratings, except that at day 7, treatment regimen also made a significant independent contribution to the prediction of satisfaction. These findings indicate that the study participants considered more than one factor when estimating their satisfaction with the study medications, and that the changes produced by the treatment (e.g. decreased pain, opioid-related symptoms) mediated, in part, the effects of treatment on treatment satisfaction.

KW - Assessment

KW - Global assessment

KW - Outcomes assessment

KW - Pain clinical trials

KW - Satisfaction

UR - http://www.scopus.com/inward/record.url?scp=3242668886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242668886&partnerID=8YFLogxK

U2 - 10.1016/j.pain.2004.04.036

DO - 10.1016/j.pain.2004.04.036

M3 - Article

VL - 110

SP - 480

EP - 487

JO - Pain

JF - Pain

SN - 0304-3959

IS - 1-2

ER -