The ambiguous boundary between genes and pseudogenes

the dead rise up, or do they?

Deyou Zheng, Mark B. Gerstein

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Pseudogenes have long been considered to be 'dead', nonfunctional by-products of genome evolution. However, several lines of evidence now show that some pseudogenes are transcriptionally 'alive', and a few might even have biochemical roles. Therefore, the boundary between genes (often considered to be 'living') and pseudogenes (often considered to be 'dead') might be ambiguous and difficult to define. Here, we examine the evidence for and against pseudogene functionality, and we argue that the time is ripe for revising the definition of a pseudogene. Furthermore, we suggest a classification system to accommodate pseudogenes with various levels of functionality.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalTrends in Genetics
Volume23
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

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Pseudogenes
Genes
Genome

ASJC Scopus subject areas

  • Genetics

Cite this

The ambiguous boundary between genes and pseudogenes : the dead rise up, or do they? / Zheng, Deyou; Gerstein, Mark B.

In: Trends in Genetics, Vol. 23, No. 5, 05.2007, p. 219-224.

Research output: Contribution to journalArticle

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