The allergic response mediated by fire ant venom proteins

Daniel Zamith-Miranda; Eduardo G.P. Fox; Ana Paula Monteiro; Diogo Gama; Luiz E. Poublan; Almair Ferreira de Araujo; Maria F.C. Araujo; Georgia C. Atella; Ednildo A. Machado; Bruno L. Diaz

doi:10.1038/s41598-018-32327-z

The allergic response mediated by fire ant venom proteins

Daniel Zamith-Miranda, Eduardo G.P. Fox, Ana Paula Monteiro, Diogo Gama, Luiz E. Poublan, Almair Ferreira de Araujo, Maria F.C. Araujo, Georgia C. Atella, Ednildo A. Machado, Bruno L. Diaz

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Fire ants are widely studied, invasive and venomous arthropod pests. There is significant biomedical interest in immunotherapy against fire ant stings. However, mainly due to practical reasons, the physiological effects of envenomation has remained poorly characterized. The present study takes advantage of a recently-described venom protein extract to delineate the immunological pathways underlying the allergic reaction to fire ant venom toxins. Mice were injected with controlled doses of venom protein extract. Following sensitization and a second exposure, a marked footpad swelling was observed. Based on eosinophil recruitment and production of Th2 cytokines, we hereby establish that fire ant proteins per se can lead to an allergic response, which casts a new light into the mechanism of action of these toxins.

Original language	English (US)
Article number	14427
Journal	Scientific reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-32327-z
State	Published - Dec 1 2018
Externally published	Yes

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title = "The allergic response mediated by fire ant venom proteins",

abstract = "Fire ants are widely studied, invasive and venomous arthropod pests. There is significant biomedical interest in immunotherapy against fire ant stings. However, mainly due to practical reasons, the physiological effects of envenomation has remained poorly characterized. The present study takes advantage of a recently-described venom protein extract to delineate the immunological pathways underlying the allergic reaction to fire ant venom toxins. Mice were injected with controlled doses of venom protein extract. Following sensitization and a second exposure, a marked footpad swelling was observed. Based on eosinophil recruitment and production of Th2 cytokines, we hereby establish that fire ant proteins per se can lead to an allergic response, which casts a new light into the mechanism of action of these toxins.",

author = "Daniel Zamith-Miranda and Fox, {Eduardo G.P.} and Monteiro, {Ana Paula} and Diogo Gama and Poublan, {Luiz E.} and {de Araujo}, {Almair Ferreira} and Araujo, {Maria F.C.} and Atella, {Georgia C.} and Machado, {Ednildo A.} and Diaz, {Bruno L.}",

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doi = "10.1038/s41598-018-32327-z",

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AU - Fox, Eduardo G.P.

AU - Monteiro, Ana Paula

AU - Gama, Diogo

AU - Poublan, Luiz E.

AU - de Araujo, Almair Ferreira

AU - Araujo, Maria F.C.

AU - Atella, Georgia C.

AU - Machado, Ednildo A.

AU - Diaz, Bruno L.

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AB - Fire ants are widely studied, invasive and venomous arthropod pests. There is significant biomedical interest in immunotherapy against fire ant stings. However, mainly due to practical reasons, the physiological effects of envenomation has remained poorly characterized. The present study takes advantage of a recently-described venom protein extract to delineate the immunological pathways underlying the allergic reaction to fire ant venom toxins. Mice were injected with controlled doses of venom protein extract. Following sensitization and a second exposure, a marked footpad swelling was observed. Based on eosinophil recruitment and production of Th2 cytokines, we hereby establish that fire ant proteins per se can lead to an allergic response, which casts a new light into the mechanism of action of these toxins.

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The allergic response mediated by fire ant venom proteins

Abstract

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