The adrenal glands from 9 patients with hereditary adreno leukodystrophy were studied. Unique changes were found in the zona fasciculata and reticularis in 8 of the cases. These changes consisted of ballooned cortical cells, many of which had a striated cytoplasm with macrovacuoles. This spectrum of change suggests that the evolution of adrenal atrophy in this disease is a primary adrenolytic process. An autoimmune process, previously proposed in this condition, now seems unlikely.
|Original language||English (US)|
|Number of pages||6|
|Journal||Archives of Pathology and Laboratory Medicine|
|State||Published - Dec 1 1973|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medical Laboratory Technology