The acute effects of acrylamide on astrocyte functions

Michael Aschner, Cheng Chen Cao, Qi Wu, Marvin A. Friedman

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We assessed biochemical endpoints indicative of acute toxicity in neonatal rat primary astrocyte cultures exposed to acrylamide. Metallothionein (MT), glutamine synthetase (GS), glutamate/aspartate transporter (GLAST), and taurine transporter (tau-T) mRNA expression levels as well as cell volume were determined in astrocytes acutely treated with 0.1 and 1.0 mM acrylamide. Statistically significant changes in acrylamide treated astrocytes were noted for GS (0.1 mM) and GLAST (1.0 mM) mRNA expression levels. All other measurements were insignificant in comparison with controls, suggesting that astrocytic function is minimally compromised even at exceedingly high levels of acute acrylamide exposure.

Original languageEnglish (US)
Pages (from-to)296-304
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume993
DOIs
Publication statusPublished - Jan 1 2003
Externally publishedYes

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Keywords

  • Acrylamide
  • Astrocyte function
  • Glutamate
  • Metallothionein

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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