The Absence of Proximal Strain in the Truncated Hemoglobins from Mycobacterium tuberculosis

Uri Samuni, Yannick Ouellet, Michel Guertin, Joel M. Friedman, Syun Ru Yeh

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

HbN and HbO are two truncated hemoglobins from Mycobacterium tuberculosis. Resonance Raman spectra of the deoxy derivatives of these two homodimeric hemoglobins indicate that there is no proximal strain imposed by intersubunit interactions on the proximal iron?histidine bond as that observed in the tetrameric human hemoglobin. In addition, with nanosecond laser flash photolysis, it was concluded that movement along the Fe?His bond following the dissociation of CO does not trigger a quaternary structural transition in these two hemoglobins.

Original languageEnglish (US)
Pages (from-to)2682-2683
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number9
DOIs
StatePublished - Mar 10 2004

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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