The Absence of Proximal Strain in the Truncated Hemoglobins from Mycobacterium tuberculosis

Uri Samuni; Yannick Ouellet; Michel Guertin; Joel M. Friedman; Syun Ru Yeh

doi:10.1021/ja038093i

The Absence of Proximal Strain in the Truncated Hemoglobins from Mycobacterium tuberculosis

Uri Samuni, Yannick Ouellet, Michel Guertin, Joel M. Friedman, Syun Ru Yeh

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

HbN and HbO are two truncated hemoglobins from Mycobacterium tuberculosis. Resonance Raman spectra of the deoxy derivatives of these two homodimeric hemoglobins indicate that there is no proximal strain imposed by intersubunit interactions on the proximal iron?histidine bond as that observed in the tetrameric human hemoglobin. In addition, with nanosecond laser flash photolysis, it was concluded that movement along the Fe?His bond following the dissociation of CO does not trigger a quaternary structural transition in these two hemoglobins.

Original language	English (US)
Pages (from-to)	2682-2683
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	9
DOIs	https://doi.org/10.1021/ja038093i
State	Published - Mar 10 2004

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/ja038093i

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abstract = "HbN and HbO are two truncated hemoglobins from Mycobacterium tuberculosis. Resonance Raman spectra of the deoxy derivatives of these two homodimeric hemoglobins indicate that there is no proximal strain imposed by intersubunit interactions on the proximal iron?histidine bond as that observed in the tetrameric human hemoglobin. In addition, with nanosecond laser flash photolysis, it was concluded that movement along the Fe?His bond following the dissociation of CO does not trigger a quaternary structural transition in these two hemoglobins.",

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AU - Guertin, Michel

AU - Friedman, Joel M.

AU - Yeh, Syun Ru

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N2 - HbN and HbO are two truncated hemoglobins from Mycobacterium tuberculosis. Resonance Raman spectra of the deoxy derivatives of these two homodimeric hemoglobins indicate that there is no proximal strain imposed by intersubunit interactions on the proximal iron?histidine bond as that observed in the tetrameric human hemoglobin. In addition, with nanosecond laser flash photolysis, it was concluded that movement along the Fe?His bond following the dissociation of CO does not trigger a quaternary structural transition in these two hemoglobins.

AB - HbN and HbO are two truncated hemoglobins from Mycobacterium tuberculosis. Resonance Raman spectra of the deoxy derivatives of these two homodimeric hemoglobins indicate that there is no proximal strain imposed by intersubunit interactions on the proximal iron?histidine bond as that observed in the tetrameric human hemoglobin. In addition, with nanosecond laser flash photolysis, it was concluded that movement along the Fe?His bond following the dissociation of CO does not trigger a quaternary structural transition in these two hemoglobins.

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The Absence of Proximal Strain in the Truncated Hemoglobins from Mycobacterium tuberculosis

Abstract

ASJC Scopus subject areas

UN SDGs

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