The 5q- deletion: Correlation of breakpoints with the immunophenotype of leukemic blast cells

Elisabeth M. Paietta, P. Papenhausen, Rasim A. Gucalp, J. Reed, P. H. Wiernik

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Abstract

Cytogenetic and immunologic features of 13 patients with the 5q- deletion with the diagnosis of acute leukemia, either as the blastic transformation of a typical 5q- syndrome or myeloproliferative disorder or as a de novo presentation, were studied. Variable 5q- breakpoints were identified: the common interstitial deletion at q13q33 was found in nine cases, and a terminal deletion at q13, q22, q22, q31, respectively, was found in four cases, two of which had unbalanced translocations. A comparison of 5q- breakpoints with the blast cell immunophenotype indicated an association of myeloid and TdT+/myeloid leukemias with interstitial deletions and of monoblastic phenotypes with terminal deletions.

Original languageEnglish (US)
Pages (from-to)822-824
Number of pages3
JournalLeukemia
Volume1
Issue number12
StatePublished - 1987

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Myeloproliferative Disorders
Myeloid Leukemia
Cytogenetics
Leukemia
Phenotype
Chromosome 5q Deletion Syndrome

ASJC Scopus subject areas

  • Cancer Research
  • Hematology

Cite this

The 5q- deletion : Correlation of breakpoints with the immunophenotype of leukemic blast cells. / Paietta, Elisabeth M.; Papenhausen, P.; Gucalp, Rasim A.; Reed, J.; Wiernik, P. H.

In: Leukemia, Vol. 1, No. 12, 1987, p. 822-824.

Research output: Contribution to journalArticle

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