Abstract
Cytogenetic and immunologic features of 13 patients with the 5q- deletion with the diagnosis of acute leukemia, either as the blastic transformation of a typical 5q- syndrome or myeloproliferative disorder or as a de novo presentation, were studied. Variable 5q- breakpoints were identified: the common interstitial deletion at q13q33 was found in nine cases, and a terminal deletion at q13, q22, q22, q31, respectively, was found in four cases, two of which had unbalanced translocations. A comparison of 5q- breakpoints with the blast cell immunophenotype indicated an association of myeloid and TdT+/myeloid leukemias with interstitial deletions and of monoblastic phenotypes with terminal deletions.
Original language | English (US) |
---|---|
Pages (from-to) | 822-824 |
Number of pages | 3 |
Journal | Leukemia |
Volume | 1 |
Issue number | 12 |
State | Published - 1987 |
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research