The 5-HT 2A receptor and serotonin transporter in Asperger's Disorder: A PET study with [ 11C]MDL 100907 and [ 11C]DASB

Ragy R. Girgis, Mark Slifstein, Xiaoyan Xu, W. Gordon Frankle, Evdokia Anagnostou, Stacey Wasserman, Lauren Pepa, Alexander Kolevzon, Anissa Abi-Dargham, Marc Laruelle, Eric Hollander

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Evidence from biochemical, imaging, and treatment studies suggest abnormalities of the serotonin system in autism spectrum disorders, in particular in frontolimbic areas of the brain. We used the radiotracers [ 11C]MDL 100907 and [ 11C]DASB to characterize the 5-HT 2A receptor and serotonin transporter in Asperger's Disorder. Seventeen individuals with Asperger's Disorder (age=34.3±11.1years) and 17 healthy controls (age=33.0±9.6years) were scanned with [ 11C]MDL 100907. Of the 17 patients, eight (age=29.7±7.0years) were also scanned with [ 11C]DASB, as were eight healthy controls (age=28.7±7.0years). Patients with Asperger's Disorder and healthy control subjects were matched for age, gender, and ethnicity, and all had normal intelligence. Metabolite-corrected arterial plasma inputs were collected and data analyzed by two-tissue compartment modeling. The primary outcome measure was regional binding potential BP ND. Neither regional [ 11C]MDL 100907 BP ND nor [ 11C]DASB BP ND was statistically different between the Asperger's and healthy subjects. This study failed to find significant alterations in binding parameters of 5-HT 2A receptors and serotonin transporters in adult subjects with Asperger's Disorder.

Original languageEnglish (US)
Pages (from-to)230-234
Number of pages5
JournalPsychiatry Research - Neuroimaging
Volume194
Issue number3
DOIs
StatePublished - Dec 30 2011

Keywords

  • 5-HT receptor
  • Asperger's Disorder
  • Autism spectrum disorders
  • Positron emission tomography
  • Serotonin
  • Serotonin transporter

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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