The 14th International Workshops on Opportunistic Protists (IWOP 14)

Melanie T. Cushion, Andrew H. Limper, Aleksey Porollo, Vivian E. Saper, Anthony P. Sinai, Louis M. Weiss

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The 14th International Workshops on Opportunistic Protists (IWOP-14) was held August 10–12, 2017 in Cincinnati, OH, USA. The IWOP meetings focus on opportunistic protists (OIs); for example, free-living amoebae, Pneumocystis spp., Cryptosporidium spp., Toxoplasma, the Microsporidia, and kinetoplastid flagellates. The highlights of Pneumocystis spp. research included the reports of primary homothallism for mating; a potential requirement for sexual replication in its life cycle; a new antigen on the surface of small asci; roles for CLRs, Dectin-1, and Mincle in host responses; and identification of MSG families and mechanisms used for surface variation. Studies of Cryptosporidia spp. included comparative genomics, a new cryopreservation method; the role of mucin in attachment and invasion, and epidemiological surveys illustrating species diversity in animals. One of the five identified proteins in the polar tube of Microsporidia, PTP4, was shown to play a role in host infection. Zebrafish were used as a low cost vertebrate animal model for an evaluation of potential anti-toxoplasma drugs. Folk medicine compounds with anti-toxoplasma activity were presented, and reports on the chronic toxoplasma infection provided evidence for increased tractability for the study of this difficult life cycle stage. Escape from the parasitophorus vacuole and cell cycle regulation were the topics of the study in the acute phase.

Original languageEnglish (US)
Pages (from-to)934-939
Number of pages6
JournalJournal of Eukaryotic Microbiology
Volume65
Issue number6
DOIs
StatePublished - Nov 1 2018

Keywords

  • Cryptosporidium
  • HIV
  • Microsporidia
  • Naegleria
  • PCP
  • Pneumocystis
  • Toxoplasma gondii
  • opportunistic infections
  • pneumonia

ASJC Scopus subject areas

  • Microbiology

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