Thalamic degeneration in X-chromosome-linked copper malabsorption

M. Iwata, A. Hirano, J. H. French

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Thalamic degeneration was present in 5 autopsied cases of C-chromosome-linked copper malabsorption (X-cLCM), Menkes' kinky hair disease. Among the thalamic nuclei, those in the formatio paraventricularis, intralamellaris, and extralamellaris were spared. The nuclei projecting to the granular cortices had severe neuronal depopulation. The thalamic nuclei that send axons to the agranular cortices were less often and less severely involved. The thalamic afferent system was intact except for degeneration of the red nucleus. Cerebral cortical lesions varied from case to case and usually were less marked than thalamic neuronal changes.

Original languageEnglish (US)
Pages (from-to)359-366
Number of pages8
JournalAnnals of Neurology
Volume5
Issue number4
StatePublished - 1979

Fingerprint

Thalamic Nuclei
X Chromosome
Copper
Chromosomes, Human, 6-12 and X
Menkes Kinky Hair Syndrome
Red Nucleus
Axons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Iwata, M., Hirano, A., & French, J. H. (1979). Thalamic degeneration in X-chromosome-linked copper malabsorption. Annals of Neurology, 5(4), 359-366.

Thalamic degeneration in X-chromosome-linked copper malabsorption. / Iwata, M.; Hirano, A.; French, J. H.

In: Annals of Neurology, Vol. 5, No. 4, 1979, p. 359-366.

Research output: Contribution to journalArticle

Iwata, M, Hirano, A & French, JH 1979, 'Thalamic degeneration in X-chromosome-linked copper malabsorption', Annals of Neurology, vol. 5, no. 4, pp. 359-366.
Iwata, M. ; Hirano, A. ; French, J. H. / Thalamic degeneration in X-chromosome-linked copper malabsorption. In: Annals of Neurology. 1979 ; Vol. 5, No. 4. pp. 359-366.
@article{254dcb4af1754ab09049b7fce9cd608e,
title = "Thalamic degeneration in X-chromosome-linked copper malabsorption",
abstract = "Thalamic degeneration was present in 5 autopsied cases of C-chromosome-linked copper malabsorption (X-cLCM), Menkes' kinky hair disease. Among the thalamic nuclei, those in the formatio paraventricularis, intralamellaris, and extralamellaris were spared. The nuclei projecting to the granular cortices had severe neuronal depopulation. The thalamic nuclei that send axons to the agranular cortices were less often and less severely involved. The thalamic afferent system was intact except for degeneration of the red nucleus. Cerebral cortical lesions varied from case to case and usually were less marked than thalamic neuronal changes.",
author = "M. Iwata and A. Hirano and French, {J. H.}",
year = "1979",
language = "English (US)",
volume = "5",
pages = "359--366",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Thalamic degeneration in X-chromosome-linked copper malabsorption

AU - Iwata, M.

AU - Hirano, A.

AU - French, J. H.

PY - 1979

Y1 - 1979

N2 - Thalamic degeneration was present in 5 autopsied cases of C-chromosome-linked copper malabsorption (X-cLCM), Menkes' kinky hair disease. Among the thalamic nuclei, those in the formatio paraventricularis, intralamellaris, and extralamellaris were spared. The nuclei projecting to the granular cortices had severe neuronal depopulation. The thalamic nuclei that send axons to the agranular cortices were less often and less severely involved. The thalamic afferent system was intact except for degeneration of the red nucleus. Cerebral cortical lesions varied from case to case and usually were less marked than thalamic neuronal changes.

AB - Thalamic degeneration was present in 5 autopsied cases of C-chromosome-linked copper malabsorption (X-cLCM), Menkes' kinky hair disease. Among the thalamic nuclei, those in the formatio paraventricularis, intralamellaris, and extralamellaris were spared. The nuclei projecting to the granular cortices had severe neuronal depopulation. The thalamic nuclei that send axons to the agranular cortices were less often and less severely involved. The thalamic afferent system was intact except for degeneration of the red nucleus. Cerebral cortical lesions varied from case to case and usually were less marked than thalamic neuronal changes.

UR - http://www.scopus.com/inward/record.url?scp=0018293931&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018293931&partnerID=8YFLogxK

M3 - Article

C2 - 443770

AN - SCOPUS:0018293931

VL - 5

SP - 359

EP - 366

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 4

ER -