@article{a40d47fcfd924b51849cdff964dbbf3d,
title = "TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment",
abstract = "Le et al. show that the TGF-β1-TGFβR kinase-SMAD3 pathway protects leukemia cells from PARP inhibitor (PARPi)-mediated synthetic lethality in the bone marrow microenvironment. The targeting of the TGF-β1 axis restored the sensitivity of leukemia cells to PARPi and prolonged survival of leukemia-bearing mice.",
keywords = "PARP inhibitor resistance, TGFβR signaling, bone marrow microenvironment",
author = "Le, {Bac Viet} and Paulina Podszywalow-Bartnicka and Silvia Maifrede and Katherine Sullivan-Reed and Margaret Nieborowska-Skorska and Konstantin Golovine and Yao, {Juo Chin} and Reza Nejati and Cai, {Kathy Q.} and Caruso, {Lisa Beatrice} and Julian Swatler and Michal Dabrowski and Zhaorui Lian and Peter Valent and Paietta, {Elisabeth M.} and Levine, {Ross L.} and Fernandez, {Hugo F.} and Tallman, {Martin S.} and Litzow, {Mark R.} and Jian Huang and Challen, {Grant A.} and Daniel Link and Italo Tempera and Wasik, {Mariusz A.} and Katarzyna Piwocka and Tomasz Skorski",
note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = oct,
day = "6",
doi = "10.1016/j.celrep.2020.108221",
language = "English (US)",
volume = "33",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}