Tezosentan and right ventricular failure in patients with pulmonary hypertension undergoing cardiac surgery: The TACTICS trial

André Y. Denault, Ronald G. Pearl, Robert E. Michler, Vivek Rao, Steven S.L. Tsui, Rainald Seitelberger, Matt Cromie, Elisabet Lindberg, Andrea M. D'Armini

Research output: Contribution to journalArticle

27 Scopus citations


Objective: To evaluate the efficacy of tezosentan in reducing the incidence of right ventricular (RV) failure and associated mortality in patients with pre-existing pulmonary hypertension. The primary endpoint was the proportion of patients with RV failure during weaning from cardiopulmonary bypass (CPB), assessed 30 minutes after the end of CPB. Design: Multicenter, double-blind, randomized, placebo-controlled trial. Setting: Thirty-one cardiac surgical centers in 14 countries. Participants: Two hundred seventy-four patients with pulmonary hypertension aged≥18 years scheduled to undergo cardiac surgery. Intervention: Intravenous tezosentan (5 mg/h) during surgery and up to 24 hours afterwards (1 mg/h), or matched placebo. Measurements and Main Results: One-hundred thirty-three patients received tezosentan and 141 placebo. RV failure occurred in 30 patients (10.9%), 37% of whom died. There was no difference in the incidence of RV failure between the two treatment groups (relative risk reduction: 0.07 [95% CI-0.83, 0.53; P = 0.8278]). Conclusion: A reduction in RV failure with tezosentan was not observed in this study.(Current Controlled Trials, identifier NCT00458276).

Original languageEnglish (US)
Pages (from-to)1212-1217
Number of pages6
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number6
Publication statusPublished - Dec 1 2013



  • cardiopulmonary bypass
  • endothelin receptor antagonist
  • left-sided heart disease
  • pulmonary hypertension
  • right ventricular failure
  • tezosentan

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine

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