Testing the disgust conditioning theory of food-avoidance in adolescents with recent onset anorexia nervosa

Tom Hildebrandt, Andrew Grotzinger, Marianne Reddan, Rebecca Greif, Ifat Levy, Wayne Goodman, Daniela Schiller

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Anorexia nervosa is characterized by chronic food avoidance that is resistant to change. Disgust conditioning offers one potential unexplored mechanism for explaining this behavioral disturbance because of its specific role in facilitating food avoidance in adaptive situations. A food based reversal learning paradigm was used to study response flexibility in 14 adolescent females with restricting subtype anorexia nervosa (AN-R) and 15 healthy control (HC) participants. Expectancy ratings were coded as a behavioral measure of flexibility and electromyography recordings from the levator labii (disgust), zygomaticus major (pleasure), and corrugator (general negative affect) provided psychophysiological measures of emotion. Response inflexibility was higher for participants with AN-R, as evidenced by lower extinction and updated expectancy ratings during reversal. EMG responses to food stimuli were predictive of both extinction and new learning. Among AN-R patients, disgust specific responses to food were associated with impaired extinction, as were elevated pleasure responses to the cued absence of food. Disgust conditioning appears to influence food learning in acutely ill patients with AN-R and may be maintained by counter-regulatory acquisition of a pleasure response to food avoidance and an aversive response to food presence. Developing strategies to target disgust may improve existing interventions for patients with AN.

Original languageEnglish (US)
Pages (from-to)131-138
Number of pages8
JournalBehaviour Research and Therapy
Volume71
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

Keywords

  • Anorexia nervosa
  • Electromyography
  • Emotion
  • Food learning
  • Reversal learning

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Clinical Psychology
  • Psychiatry and Mental health

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