Tendon healing: Repair and regeneration

Pramod B. Voleti, Mark R. Buckley, Louis J. Soslowsky

Research output: Contribution to journalReview article

142 Scopus citations

Abstract

Injury and degeneration of tendon, the soft tissue that mechanically links muscle and bone, can cause substantial pain and loss of function. This review discusses the composition and function of healthy tendon and describes the structural, biological, and mechanical changes initiated during the process of tendon healing. Biochemical pathways activated during repair, experimental injury models, and parallels between tendon healing and tendon development are emphasized, and cutting-edge strategies for the enhancement of tendon healing are discussed.

Original languageEnglish (US)
Pages (from-to)47-71
Number of pages25
JournalAnnual Review of Biomedical Engineering
Volume14
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Keywords

  • Tendon
  • Tendon animal models
  • Tendon injury
  • Tendon mechanics
  • Tendon repair

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

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