Abstract
Background and Objectives: Immunohistochemical methods were used to study Tenascin (TN) expression in invasive duct cell carcinoma (IDCC) of the breast and its established prognostic factors. Methods: We studied 115 patients with IDCC. The mean patient age was 62 years; all tumors were graded according to Scarf-Bloom and Richardson. Complete survival information was available for all patients (median follow-up 65 months). Formalin-fixed, paraffin-embedded archival tissue from all 115 IDCC were immunostained with monoclonal mouse AntiHuman Tenascin (DAKO-TN2M636; 1/50 dilution). Positivity was recorded on a scale of 0-4 for percentage of TN staining in the tumor stroma. Results: TN showed thick bands around advancing tumor nests and in poorly differentiated tumors, TN fibers had an interstitial pattern surrounding single tumor cells. TN score was significantly positively correlated with high nuclear grade (P < 0.05), bistologic grade (P < 0.01), mitotic grade (P < 0.005), and combined grade (P < 0.01). TN score did not correlate with long-term survival or with other prognostic factors studied. Conclusions: TN expression was more prominent in tumors with a high combined histologic grade. Our results may suggest that while TN may play a role in limiting tumor spread as proposed by other studies, it may not represent a prognostic factor in invasive breast carcinoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 107-112 |
| Number of pages | 6 |
| Journal | Journal of Surgical Oncology |
| Volume | 68 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1998 |
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Keywords
- Adhesion molecule
- Extracellular matrix
- Glycoprotein
ASJC Scopus subject areas
- Surgery
- Oncology
Cite this
Tenascin pattern of expression and established prognostic factors in invasive breast carcinoma. / Iskaros, Basem F.; Hu, Xiaoping; Sparano, Joseph A.; Fineberg, Susan A.
In: Journal of Surgical Oncology, Vol. 68, No. 2, 06.1998, p. 107-112.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tenascin pattern of expression and established prognostic factors in invasive breast carcinoma
AU - Iskaros, Basem F.
AU - Hu, Xiaoping
AU - Sparano, Joseph A.
AU - Fineberg, Susan A.
PY - 1998/6
Y1 - 1998/6
N2 - Background and Objectives: Immunohistochemical methods were used to study Tenascin (TN) expression in invasive duct cell carcinoma (IDCC) of the breast and its established prognostic factors. Methods: We studied 115 patients with IDCC. The mean patient age was 62 years; all tumors were graded according to Scarf-Bloom and Richardson. Complete survival information was available for all patients (median follow-up 65 months). Formalin-fixed, paraffin-embedded archival tissue from all 115 IDCC were immunostained with monoclonal mouse AntiHuman Tenascin (DAKO-TN2M636; 1/50 dilution). Positivity was recorded on a scale of 0-4 for percentage of TN staining in the tumor stroma. Results: TN showed thick bands around advancing tumor nests and in poorly differentiated tumors, TN fibers had an interstitial pattern surrounding single tumor cells. TN score was significantly positively correlated with high nuclear grade (P < 0.05), bistologic grade (P < 0.01), mitotic grade (P < 0.005), and combined grade (P < 0.01). TN score did not correlate with long-term survival or with other prognostic factors studied. Conclusions: TN expression was more prominent in tumors with a high combined histologic grade. Our results may suggest that while TN may play a role in limiting tumor spread as proposed by other studies, it may not represent a prognostic factor in invasive breast carcinoma.
AB - Background and Objectives: Immunohistochemical methods were used to study Tenascin (TN) expression in invasive duct cell carcinoma (IDCC) of the breast and its established prognostic factors. Methods: We studied 115 patients with IDCC. The mean patient age was 62 years; all tumors were graded according to Scarf-Bloom and Richardson. Complete survival information was available for all patients (median follow-up 65 months). Formalin-fixed, paraffin-embedded archival tissue from all 115 IDCC were immunostained with monoclonal mouse AntiHuman Tenascin (DAKO-TN2M636; 1/50 dilution). Positivity was recorded on a scale of 0-4 for percentage of TN staining in the tumor stroma. Results: TN showed thick bands around advancing tumor nests and in poorly differentiated tumors, TN fibers had an interstitial pattern surrounding single tumor cells. TN score was significantly positively correlated with high nuclear grade (P < 0.05), bistologic grade (P < 0.01), mitotic grade (P < 0.005), and combined grade (P < 0.01). TN score did not correlate with long-term survival or with other prognostic factors studied. Conclusions: TN expression was more prominent in tumors with a high combined histologic grade. Our results may suggest that while TN may play a role in limiting tumor spread as proposed by other studies, it may not represent a prognostic factor in invasive breast carcinoma.
KW - Adhesion molecule
KW - Extracellular matrix
KW - Glycoprotein
UR - http://www.scopus.com/inward/record.url?scp=0031811561&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031811561&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-9098(199806)68:2<107::AID-JSO7>3.0.CO;2-A
DO - 10.1002/(SICI)1096-9098(199806)68:2<107::AID-JSO7>3.0.CO;2-A
M3 - Article
C2 - 9624040
AN - SCOPUS:0031811561
VL - 68
SP - 107
EP - 112
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 2
ER -