Ten-year predicted coronary heart disease risk in HIV-infected men and women

Robert C. Kaplan, Lawrence A. Kingsley, A. Richey Sharrett, Xiuhong Li, Jason Lazar, Phyllis C. Tien, Wendy J. Mack, Mardge H. Cohen, Lisa Jacobson, Stephen J. Gange

Research output: Contribution to journalArticle

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Abstract

Background. Highly active antiretroviral therapy (HAART), in addition to traditional vascular risk factors, may affect coronary heart disease (CHD) risk in individuals with human immunodeficiency virus (HIV) infection. Methods. Among HIV-infected (931 men and 1455 women) and HIV-uninfected (1099 men and 576 women) adults, the predicted risk of CHD was estimated on the basis of age, sex, lipid and blood pressure levels, the presence of diabetes, and smoking status. Results. Among HIV-infected men, 2% had moderate predicted risk of CHD (10-year CHD risk, 15%-25%), and 17% had high predicted risk (10-year CHD risk of ≥25% or diabetes). Among HIV-infected women, 2% had moderate predicted CHD risk, and 12% had high predicted CHD risk. Compared with users of protease inhibitor-based HAART, the adjusted odds ratio (OR) for moderate-to-high risk of CHD was significantly lower among HAART-naive individuals (OR, 0.57; 95% confidence interval [CI], 0.36-0.89). Users of HAART that was not protease inhibitor based (OR, 0.74; 95% CI, 0.53-1.01) and former HAART users (OR, 0.68; 95% CI, 0.46-1.03) were also less likely than users of protease inhibitor-based HAART to have moderate-to-high CHD risk, although 95% CIs overlapped the null. Low income was associated with increased likelihood of moderate-to-high CHD risk (for annual income <$10,000 vs. >$40,000: OR, 2.32; 95% CI, 1.51-3.56 ). Elevated body mass index (calculated as weight in kilograms divided by the square of height in meters) predicted increased likelihood of moderate-to-high CHD risk (for BMI of 18.5-24.9 vs. BMI of 25-30: OR, 1.41 [95% CI, 1.03-1.93]; for BMI of 18.5-24.9 vs. BMI ≥30: OR, 1.79 [95% CI, 1.25-2.56]). Conclusions. Among HIV-infected adults, in addition to antiretroviral drug exposures, being overweight and having a low income level were associated with increased predicted CHD risk. This suggests a need to target HIV-infected men and women with these characteristics for vascular risk factor screening.

Original languageEnglish (US)
Pages (from-to)1074-1081
Number of pages8
JournalClinical Infectious Diseases
Volume45
Issue number8
DOIs
StatePublished - 2007

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Coronary Disease
HIV
Highly Active Antiretroviral Therapy
Odds Ratio
Confidence Intervals
Protease Inhibitors
Virus Diseases
Body Mass Index
Smoking
Blood Pressure
Lipids
Weights and Measures

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this

Kaplan, R. C., Kingsley, L. A., Sharrett, A. R., Li, X., Lazar, J., Tien, P. C., ... Gange, S. J. (2007). Ten-year predicted coronary heart disease risk in HIV-infected men and women. Clinical Infectious Diseases, 45(8), 1074-1081. https://doi.org/10.1086/521935

Ten-year predicted coronary heart disease risk in HIV-infected men and women. / Kaplan, Robert C.; Kingsley, Lawrence A.; Sharrett, A. Richey; Li, Xiuhong; Lazar, Jason; Tien, Phyllis C.; Mack, Wendy J.; Cohen, Mardge H.; Jacobson, Lisa; Gange, Stephen J.

In: Clinical Infectious Diseases, Vol. 45, No. 8, 2007, p. 1074-1081.

Research output: Contribution to journalArticle

Kaplan, RC, Kingsley, LA, Sharrett, AR, Li, X, Lazar, J, Tien, PC, Mack, WJ, Cohen, MH, Jacobson, L & Gange, SJ 2007, 'Ten-year predicted coronary heart disease risk in HIV-infected men and women', Clinical Infectious Diseases, vol. 45, no. 8, pp. 1074-1081. https://doi.org/10.1086/521935
Kaplan, Robert C. ; Kingsley, Lawrence A. ; Sharrett, A. Richey ; Li, Xiuhong ; Lazar, Jason ; Tien, Phyllis C. ; Mack, Wendy J. ; Cohen, Mardge H. ; Jacobson, Lisa ; Gange, Stephen J. / Ten-year predicted coronary heart disease risk in HIV-infected men and women. In: Clinical Infectious Diseases. 2007 ; Vol. 45, No. 8. pp. 1074-1081.
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abstract = "Background. Highly active antiretroviral therapy (HAART), in addition to traditional vascular risk factors, may affect coronary heart disease (CHD) risk in individuals with human immunodeficiency virus (HIV) infection. Methods. Among HIV-infected (931 men and 1455 women) and HIV-uninfected (1099 men and 576 women) adults, the predicted risk of CHD was estimated on the basis of age, sex, lipid and blood pressure levels, the presence of diabetes, and smoking status. Results. Among HIV-infected men, 2{\%} had moderate predicted risk of CHD (10-year CHD risk, 15{\%}-25{\%}), and 17{\%} had high predicted risk (10-year CHD risk of ≥25{\%} or diabetes). Among HIV-infected women, 2{\%} had moderate predicted CHD risk, and 12{\%} had high predicted CHD risk. Compared with users of protease inhibitor-based HAART, the adjusted odds ratio (OR) for moderate-to-high risk of CHD was significantly lower among HAART-naive individuals (OR, 0.57; 95{\%} confidence interval [CI], 0.36-0.89). Users of HAART that was not protease inhibitor based (OR, 0.74; 95{\%} CI, 0.53-1.01) and former HAART users (OR, 0.68; 95{\%} CI, 0.46-1.03) were also less likely than users of protease inhibitor-based HAART to have moderate-to-high CHD risk, although 95{\%} CIs overlapped the null. Low income was associated with increased likelihood of moderate-to-high CHD risk (for annual income <$10,000 vs. >$40,000: OR, 2.32; 95{\%} CI, 1.51-3.56 ). Elevated body mass index (calculated as weight in kilograms divided by the square of height in meters) predicted increased likelihood of moderate-to-high CHD risk (for BMI of 18.5-24.9 vs. BMI of 25-30: OR, 1.41 [95{\%} CI, 1.03-1.93]; for BMI of 18.5-24.9 vs. BMI ≥30: OR, 1.79 [95{\%} CI, 1.25-2.56]). Conclusions. Among HIV-infected adults, in addition to antiretroviral drug exposures, being overweight and having a low income level were associated with increased predicted CHD risk. This suggests a need to target HIV-infected men and women with these characteristics for vascular risk factor screening.",
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T1 - Ten-year predicted coronary heart disease risk in HIV-infected men and women

AU - Kaplan, Robert C.

AU - Kingsley, Lawrence A.

AU - Sharrett, A. Richey

AU - Li, Xiuhong

AU - Lazar, Jason

AU - Tien, Phyllis C.

AU - Mack, Wendy J.

AU - Cohen, Mardge H.

AU - Jacobson, Lisa

AU - Gange, Stephen J.

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N2 - Background. Highly active antiretroviral therapy (HAART), in addition to traditional vascular risk factors, may affect coronary heart disease (CHD) risk in individuals with human immunodeficiency virus (HIV) infection. Methods. Among HIV-infected (931 men and 1455 women) and HIV-uninfected (1099 men and 576 women) adults, the predicted risk of CHD was estimated on the basis of age, sex, lipid and blood pressure levels, the presence of diabetes, and smoking status. Results. Among HIV-infected men, 2% had moderate predicted risk of CHD (10-year CHD risk, 15%-25%), and 17% had high predicted risk (10-year CHD risk of ≥25% or diabetes). Among HIV-infected women, 2% had moderate predicted CHD risk, and 12% had high predicted CHD risk. Compared with users of protease inhibitor-based HAART, the adjusted odds ratio (OR) for moderate-to-high risk of CHD was significantly lower among HAART-naive individuals (OR, 0.57; 95% confidence interval [CI], 0.36-0.89). Users of HAART that was not protease inhibitor based (OR, 0.74; 95% CI, 0.53-1.01) and former HAART users (OR, 0.68; 95% CI, 0.46-1.03) were also less likely than users of protease inhibitor-based HAART to have moderate-to-high CHD risk, although 95% CIs overlapped the null. Low income was associated with increased likelihood of moderate-to-high CHD risk (for annual income <$10,000 vs. >$40,000: OR, 2.32; 95% CI, 1.51-3.56 ). Elevated body mass index (calculated as weight in kilograms divided by the square of height in meters) predicted increased likelihood of moderate-to-high CHD risk (for BMI of 18.5-24.9 vs. BMI of 25-30: OR, 1.41 [95% CI, 1.03-1.93]; for BMI of 18.5-24.9 vs. BMI ≥30: OR, 1.79 [95% CI, 1.25-2.56]). Conclusions. Among HIV-infected adults, in addition to antiretroviral drug exposures, being overweight and having a low income level were associated with increased predicted CHD risk. This suggests a need to target HIV-infected men and women with these characteristics for vascular risk factor screening.

AB - Background. Highly active antiretroviral therapy (HAART), in addition to traditional vascular risk factors, may affect coronary heart disease (CHD) risk in individuals with human immunodeficiency virus (HIV) infection. Methods. Among HIV-infected (931 men and 1455 women) and HIV-uninfected (1099 men and 576 women) adults, the predicted risk of CHD was estimated on the basis of age, sex, lipid and blood pressure levels, the presence of diabetes, and smoking status. Results. Among HIV-infected men, 2% had moderate predicted risk of CHD (10-year CHD risk, 15%-25%), and 17% had high predicted risk (10-year CHD risk of ≥25% or diabetes). Among HIV-infected women, 2% had moderate predicted CHD risk, and 12% had high predicted CHD risk. Compared with users of protease inhibitor-based HAART, the adjusted odds ratio (OR) for moderate-to-high risk of CHD was significantly lower among HAART-naive individuals (OR, 0.57; 95% confidence interval [CI], 0.36-0.89). Users of HAART that was not protease inhibitor based (OR, 0.74; 95% CI, 0.53-1.01) and former HAART users (OR, 0.68; 95% CI, 0.46-1.03) were also less likely than users of protease inhibitor-based HAART to have moderate-to-high CHD risk, although 95% CIs overlapped the null. Low income was associated with increased likelihood of moderate-to-high CHD risk (for annual income <$10,000 vs. >$40,000: OR, 2.32; 95% CI, 1.51-3.56 ). Elevated body mass index (calculated as weight in kilograms divided by the square of height in meters) predicted increased likelihood of moderate-to-high CHD risk (for BMI of 18.5-24.9 vs. BMI of 25-30: OR, 1.41 [95% CI, 1.03-1.93]; for BMI of 18.5-24.9 vs. BMI ≥30: OR, 1.79 [95% CI, 1.25-2.56]). Conclusions. Among HIV-infected adults, in addition to antiretroviral drug exposures, being overweight and having a low income level were associated with increased predicted CHD risk. This suggests a need to target HIV-infected men and women with these characteristics for vascular risk factor screening.

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