Temporal repolarization lability differences among genotyped patients with the long QT syndrome

Kenneth Bilchick; Matti Viitasalo; Lasse Oikarinen; Barry Fetics; Gordon Tomaselli; Heikki Swan; Päivi J. Laitinen; Heikki Väänänen; Kimmo Kontula; Ronald D. Berger

doi:10.1016/j.amjcard.2004.07.123

Temporal repolarization lability differences among genotyped patients with the long QT syndrome

Kenneth Bilchick, Matti Viitasalo, Lasse Oikarinen, Barry Fetics, Gordon Tomaselli, Heikki Swan, Päivi J. Laitinen, Heikki Väänänen, Kimmo Kontula, Ronald D. Berger

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The investigators sought to test whether certain long QT syndrome (LQTS) mutations are associated with increased repolarization lability and whether repolarization lability (quantified by the QT variability index [QTVI]) is increased in patients with LQTS compared with controls. In 32 genotyped patients with LQTS type 1 (LQT1), 32 genotyped patients with LQTS type 2 (LQT2), and 32 controls, the QTVI was increased in patients with LQT2 (-0.973 ± 0.394, p = 0.01 vs controls) and in patients with LQT1 with mutations other than KCNQ1-FIN (-0.942 ± 0.264, p = 0.04 vs controls) but was similar between the KCNQ1-FIN group and controls.

Original language	English (US)
Pages (from-to)	1312-1316
Number of pages	5
Journal	American Journal of Cardiology
Volume	94
Issue number	10
DOIs	https://doi.org/10.1016/j.amjcard.2004.07.123
State	Published - Nov 15 2004
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.amjcard.2004.07.123

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title = "Temporal repolarization lability differences among genotyped patients with the long QT syndrome",

abstract = "The investigators sought to test whether certain long QT syndrome (LQTS) mutations are associated with increased repolarization lability and whether repolarization lability (quantified by the QT variability index [QTVI]) is increased in patients with LQTS compared with controls. In 32 genotyped patients with LQTS type 1 (LQT1), 32 genotyped patients with LQTS type 2 (LQT2), and 32 controls, the QTVI was increased in patients with LQT2 (-0.973 ± 0.394, p = 0.01 vs controls) and in patients with LQT1 with mutations other than KCNQ1-FIN (-0.942 ± 0.264, p = 0.04 vs controls) but was similar between the KCNQ1-FIN group and controls.",

author = "Kenneth Bilchick and Matti Viitasalo and Lasse Oikarinen and Barry Fetics and Gordon Tomaselli and Heikki Swan and Laitinen, {P{\"a}ivi J.} and Heikki V{\"a}{\"a}n{\"a}nen and Kimmo Kontula and Berger, {Ronald D.}",

note = "Funding Information: This work was supported by grants P50 HL52307 and R44 HL61903 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland; the Finnish Foundation for Cardiovascular Research, Helsinki, Finland; the Sigrid Juselius Foundation, Helsinki, Finland; and the Finnish Academy, Helsinki, Finland. Dr. Berger is an established investigator of the American Heart Association, Dallas, Texas, and receives support from the Donald W. Reynolds Foundation, Las Vegas, Nevada. ",

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doi = "10.1016/j.amjcard.2004.07.123",

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AU - Bilchick, Kenneth

AU - Viitasalo, Matti

AU - Oikarinen, Lasse

AU - Fetics, Barry

AU - Tomaselli, Gordon

AU - Swan, Heikki

AU - Laitinen, Päivi J.

AU - Väänänen, Heikki

AU - Kontula, Kimmo

AU - Berger, Ronald D.

N1 - Funding Information: This work was supported by grants P50 HL52307 and R44 HL61903 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland; the Finnish Foundation for Cardiovascular Research, Helsinki, Finland; the Sigrid Juselius Foundation, Helsinki, Finland; and the Finnish Academy, Helsinki, Finland. Dr. Berger is an established investigator of the American Heart Association, Dallas, Texas, and receives support from the Donald W. Reynolds Foundation, Las Vegas, Nevada.

PY - 2004/11/15

Y1 - 2004/11/15

N2 - The investigators sought to test whether certain long QT syndrome (LQTS) mutations are associated with increased repolarization lability and whether repolarization lability (quantified by the QT variability index [QTVI]) is increased in patients with LQTS compared with controls. In 32 genotyped patients with LQTS type 1 (LQT1), 32 genotyped patients with LQTS type 2 (LQT2), and 32 controls, the QTVI was increased in patients with LQT2 (-0.973 ± 0.394, p = 0.01 vs controls) and in patients with LQT1 with mutations other than KCNQ1-FIN (-0.942 ± 0.264, p = 0.04 vs controls) but was similar between the KCNQ1-FIN group and controls.

AB - The investigators sought to test whether certain long QT syndrome (LQTS) mutations are associated with increased repolarization lability and whether repolarization lability (quantified by the QT variability index [QTVI]) is increased in patients with LQTS compared with controls. In 32 genotyped patients with LQTS type 1 (LQT1), 32 genotyped patients with LQTS type 2 (LQT2), and 32 controls, the QTVI was increased in patients with LQT2 (-0.973 ± 0.394, p = 0.01 vs controls) and in patients with LQT1 with mutations other than KCNQ1-FIN (-0.942 ± 0.264, p = 0.04 vs controls) but was similar between the KCNQ1-FIN group and controls.

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Temporal repolarization lability differences among genotyped patients with the long QT syndrome

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