Template-based protein structure modeling.

Research output: Contribution to journalReview article

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Abstract

Functional characterization of a protein is often facilitated by its 3D structure. However, the fraction of experimentally known 3D models is currently less than 1% due to the inherently time-consuming and complicated nature of structure determination techniques. Computational approaches are employed to bridge the gap between the number of known sequences and that of 3D models. Template-based protein structure modeling techniques rely on the study of principles that dictate the 3D structure of natural proteins from the theory of evolution viewpoint. Strategies for template-based structure modeling will be discussed with a focus on comparative modeling, by reviewing techniques available for all the major steps involved in the comparative modeling pipeline.

Original languageEnglish (US)
Pages (from-to)73-94
Number of pages22
JournalMethods in molecular biology (Clifton, N.J.)
Volume673
StatePublished - 2010

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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