Abstract
Functional characterization of a protein is often facilitated by its 3D structure. However, the fraction of experimentally known 3D models is currently less than 1% due to the inherently time-consuming and complicated nature of structure determination techniques. Computational approaches are employed to bridge the gap between the number of known sequences and that of 3D models. Template-based protein structure modeling techniques rely on the study of principles that dictate the 3D structure of natural proteins from the theory of evolution viewpoint. Strategies for template-based structure modeling will be discussed with a focus on comparative modeling, by reviewing techniques available for all the major steps involved in the comparative modeling pipeline.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 73-94 |
| Number of pages | 22 |
| Journal | Methods in molecular biology (Clifton, N.J.) |
| Volume | 673 |
| State | Published - 2010 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
Template-based protein structure modeling. / Fiser, Andras.
In: Methods in molecular biology (Clifton, N.J.), Vol. 673, 2010, p. 73-94.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Template-based protein structure modeling.
AU - Fiser, Andras
PY - 2010
Y1 - 2010
N2 - Functional characterization of a protein is often facilitated by its 3D structure. However, the fraction of experimentally known 3D models is currently less than 1% due to the inherently time-consuming and complicated nature of structure determination techniques. Computational approaches are employed to bridge the gap between the number of known sequences and that of 3D models. Template-based protein structure modeling techniques rely on the study of principles that dictate the 3D structure of natural proteins from the theory of evolution viewpoint. Strategies for template-based structure modeling will be discussed with a focus on comparative modeling, by reviewing techniques available for all the major steps involved in the comparative modeling pipeline.
AB - Functional characterization of a protein is often facilitated by its 3D structure. However, the fraction of experimentally known 3D models is currently less than 1% due to the inherently time-consuming and complicated nature of structure determination techniques. Computational approaches are employed to bridge the gap between the number of known sequences and that of 3D models. Template-based protein structure modeling techniques rely on the study of principles that dictate the 3D structure of natural proteins from the theory of evolution viewpoint. Strategies for template-based structure modeling will be discussed with a focus on comparative modeling, by reviewing techniques available for all the major steps involved in the comparative modeling pipeline.
UR - http://www.scopus.com/inward/record.url?scp=79952113376&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952113376&partnerID=8YFLogxK
M3 - Article
C2 - 20835794
AN - SCOPUS:79952113376
VL - 673
SP - 73
EP - 94
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
SN - 1064-3745
ER -