Temperature-sensitive mutants of reovirus type 3: Defects in viral maturation as studied by immunofluorescence and electron microscopy

Bernard N. Fields, Cedric S. Raine, Stephen G. Baum

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Studies using electron microscopy and immunofluorescence have been performed on cells infected with five different groups of temperature-sensitive mutants of reovirus type 3. Mutants of groups A and E induce normal appearing viral factories. Mutants of group B induce factories which accumulate viral cores, while factories of groups C and D accumulate empty viral capsids. It is suggested that the latter three genetic groups consist of mutants with defects in virion assembly.

Original languageEnglish (US)
Pages (from-to)569-578
Number of pages10
JournalVirology
Volume43
Issue number3
DOIs
StatePublished - Mar 1971

ASJC Scopus subject areas

  • Virology

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