Temperature sensitive liposome encapsulated adriamycin combined with hepatic artery embolization

Yiyu Zou, X. Q. Gu, I. M. Horikoshi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A temperature sensitive liposome composed of a vesicle membrane of dipalmitoyl phosphatidylcholine and encapsulated adriamycin was made by the modified reverse-phase evaporation method. The encapsulation efficiency measured with a centrifugal filtration method was about 38%. The phase-transition temperature of the liposome determined by DSC was 41 degrees C. The liposome size was 851 +/- 50 nm, and the size distribution was from 772 to 952 nm as measured by laser particle analyzer with dynamic light scatter method. Eighty-four percent of the encapsulated drug could be released at precisely the phase-transition temperature of liposome in vitro. The results show that the liposomal drug is sensitive to temperature-controlled release.

Original languageEnglish (US)
Pages (from-to)622-626
Number of pages5
JournalActa Pharmaceutica Sinica
Volume26
Issue number8
StatePublished - 1991
Externally publishedYes

Fingerprint

Hepatic Artery
Liposomes
Doxorubicin
Temperature
Transition Temperature
Phase Transition
1,2-Dipalmitoylphosphatidylcholine
Pharmaceutical Preparations
Lasers
Light
Membranes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Temperature sensitive liposome encapsulated adriamycin combined with hepatic artery embolization. / Zou, Yiyu; Gu, X. Q.; Horikoshi, I. M.

In: Acta Pharmaceutica Sinica, Vol. 26, No. 8, 1991, p. 622-626.

Research output: Contribution to journalArticle

@article{3ad222706adc46078b490a54e4513969,
title = "Temperature sensitive liposome encapsulated adriamycin combined with hepatic artery embolization",
abstract = "A temperature sensitive liposome composed of a vesicle membrane of dipalmitoyl phosphatidylcholine and encapsulated adriamycin was made by the modified reverse-phase evaporation method. The encapsulation efficiency measured with a centrifugal filtration method was about 38{\%}. The phase-transition temperature of the liposome determined by DSC was 41 degrees C. The liposome size was 851 +/- 50 nm, and the size distribution was from 772 to 952 nm as measured by laser particle analyzer with dynamic light scatter method. Eighty-four percent of the encapsulated drug could be released at precisely the phase-transition temperature of liposome in vitro. The results show that the liposomal drug is sensitive to temperature-controlled release.",
author = "Yiyu Zou and Gu, {X. Q.} and Horikoshi, {I. M.}",
year = "1991",
language = "English (US)",
volume = "26",
pages = "622--626",
journal = "Yao xue xue bao = Acta pharmaceutica Sinica",
issn = "0513-4870",
publisher = "Zhonghua Yixuehui Zazhishe",
number = "8",

}

TY - JOUR

T1 - Temperature sensitive liposome encapsulated adriamycin combined with hepatic artery embolization

AU - Zou, Yiyu

AU - Gu, X. Q.

AU - Horikoshi, I. M.

PY - 1991

Y1 - 1991

N2 - A temperature sensitive liposome composed of a vesicle membrane of dipalmitoyl phosphatidylcholine and encapsulated adriamycin was made by the modified reverse-phase evaporation method. The encapsulation efficiency measured with a centrifugal filtration method was about 38%. The phase-transition temperature of the liposome determined by DSC was 41 degrees C. The liposome size was 851 +/- 50 nm, and the size distribution was from 772 to 952 nm as measured by laser particle analyzer with dynamic light scatter method. Eighty-four percent of the encapsulated drug could be released at precisely the phase-transition temperature of liposome in vitro. The results show that the liposomal drug is sensitive to temperature-controlled release.

AB - A temperature sensitive liposome composed of a vesicle membrane of dipalmitoyl phosphatidylcholine and encapsulated adriamycin was made by the modified reverse-phase evaporation method. The encapsulation efficiency measured with a centrifugal filtration method was about 38%. The phase-transition temperature of the liposome determined by DSC was 41 degrees C. The liposome size was 851 +/- 50 nm, and the size distribution was from 772 to 952 nm as measured by laser particle analyzer with dynamic light scatter method. Eighty-four percent of the encapsulated drug could be released at precisely the phase-transition temperature of liposome in vitro. The results show that the liposomal drug is sensitive to temperature-controlled release.

UR - http://www.scopus.com/inward/record.url?scp=0026301856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026301856&partnerID=8YFLogxK

M3 - Article

C2 - 1805526

AN - SCOPUS:0026301856

VL - 26

SP - 622

EP - 626

JO - Yao xue xue bao = Acta pharmaceutica Sinica

JF - Yao xue xue bao = Acta pharmaceutica Sinica

SN - 0513-4870

IS - 8

ER -