Temperature sensitive liposome encapsulated adriamycin combined with hepatic artery embolization

Y. Y. Zou, X. Q. Gu, I. M. Horikoshi

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A temperature sensitive liposome composed of a vesicle membrane of dipalmitoyl phosphatidylcholine and encapsulated adriamycin was made by the modified reverse-phase evaporation method. The encapsulation efficiency measured with a centrifugal filtration method was about 38%. The phase-transition temperature of the liposome determined by DSC was 41 degrees C. The liposome size was 851 +/- 50 nm, and the size distribution was from 772 to 952 nm as measured by laser particle analyzer with dynamic light scatter method. Eighty-four percent of the encapsulated drug could be released at precisely the phase-transition temperature of liposome in vitro. The results show that the liposomal drug is sensitive to temperature-controlled release.

Original languageEnglish (US)
Pages (from-to)622-626
Number of pages5
JournalYao xue xue bao = Acta pharmaceutica Sinica
Volume26
Issue number8
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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