Temperature dependence of rat diaphragm muscle contractility and fatigue

David J. Prezant, B. Richner, D. E. Valentine, T. K. Aldrich, C. L. Fishman, H. Nagashima, I. Chaudhry, J. Cahill

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The diaphragm is a skeletal muscle of mixed fiber type that is unique in its requirement to maintain contractile function and fatigue resistance across a wide range of temperatures to sustain alveolar ventilation under conditions of hypo- or hyperthermia. The direct effect of temperature (15-41°C) on rat diaphragm isometric contractility and fatigue was determined in vitro. As temperature decreased from 37 to 15°C, contraction and relaxation times increased, and there was a left shift of the diaphragm's force-frequency curve, with decreased contractility at 41 and 15°C. Fatigue was induced by 10 min of stimulation with 30 trains/min of 5 Hz at a train duration of 900 ms. Compared with 37°C, fatigue resistance was enhanced at 25°C, but no difference in fatigue indexes was evident at extreme hypothermia (15°C) or hyperthermia (41°C). Only when the fatigue program was adjusted to account for hypothermia-induced increases in tension-time indexes was fatigue resistance evident at 15°C. These findings indicate that despite the diaphragm's unique location as a core structure, necessitating exposure to in vivo temperatures higher than found in limb muscle, the temperature dependence of rat diaphragm muscle contractility and fatigue is similar to that reported for limb muscle of mixed fiber type.

Original languageEnglish (US)
Pages (from-to)1740-1745
Number of pages6
JournalJournal of Applied Physiology
Volume69
Issue number5
StatePublished - 1990

Fingerprint

Muscle Fatigue
Diaphragm
Fatigue
Temperature
Hypothermia
Fever
Extremities
Induced Hypothermia
Muscles
Skeletal Muscle Fibers
Ventilation

Keywords

  • hyperthermia
  • hypothermia

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Prezant, D. J., Richner, B., Valentine, D. E., Aldrich, T. K., Fishman, C. L., Nagashima, H., ... Cahill, J. (1990). Temperature dependence of rat diaphragm muscle contractility and fatigue. Journal of Applied Physiology, 69(5), 1740-1745.

Temperature dependence of rat diaphragm muscle contractility and fatigue. / Prezant, David J.; Richner, B.; Valentine, D. E.; Aldrich, T. K.; Fishman, C. L.; Nagashima, H.; Chaudhry, I.; Cahill, J.

In: Journal of Applied Physiology, Vol. 69, No. 5, 1990, p. 1740-1745.

Research output: Contribution to journalArticle

Prezant, DJ, Richner, B, Valentine, DE, Aldrich, TK, Fishman, CL, Nagashima, H, Chaudhry, I & Cahill, J 1990, 'Temperature dependence of rat diaphragm muscle contractility and fatigue', Journal of Applied Physiology, vol. 69, no. 5, pp. 1740-1745.
Prezant DJ, Richner B, Valentine DE, Aldrich TK, Fishman CL, Nagashima H et al. Temperature dependence of rat diaphragm muscle contractility and fatigue. Journal of Applied Physiology. 1990;69(5):1740-1745.
Prezant, David J. ; Richner, B. ; Valentine, D. E. ; Aldrich, T. K. ; Fishman, C. L. ; Nagashima, H. ; Chaudhry, I. ; Cahill, J. / Temperature dependence of rat diaphragm muscle contractility and fatigue. In: Journal of Applied Physiology. 1990 ; Vol. 69, No. 5. pp. 1740-1745.
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