Telomestatin: Formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes

Medicine & Life Sciences

• telomestatin 100%
• G-Quadruplexes 71%
• Oxazoles 58%
• Cations 49%
• carbene 30%
• Rhodium 28%
• Synthetic Chemistry Techniques 27%
• Organic Chemicals 26%
• Monovalent Cations 23%
• Sulfur 19%
• Enzyme Inhibitors 18%
• Telomerase 18%
• Molecular Dynamics Simulation 18%
• Biological Products 16%
• Spectrum Analysis 16%
• Mass Spectrometry 14%
• Ligands 11%
• Neoplasms 5%
• Therapeutics 2%

Chemical Compounds

• Telomestatin 90%
• Total Synthesis 42%
• Oxazole 39%
• Rhodium Carbene 27%
• Monoatomic Monocation 19%
• Macrocycle 15%
• Occurrence in Nature 13%
• Kd 12%
• Molecular Dynamics 11%
• Mass Spectrometry 10%
• Spectroscopy 10%
• Simulation 10%
• Ligand 7%

Engineering & Materials Science

• Derivatives 40%
• Rhodium 37%
• Organic chemicals 37%
• Ligands 32%
• Mass spectrometry 31%
• Enzymes 28%
• Molecular dynamics 27%
• Spectroscopy 27%
• Sulfur 23%
• Computer simulation 13%