Telomere length regulation through epidermal growth factor receptor signaling in cancer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Length of the telomere (TL), a structure at the tip of chromosome that protects and ensures stability, is determined by multi-protein complexes such as telosome/ shelterin and telomerase. Earlier studies from our laboratory show that longer TL has potential to be positive predictive biomarker of clinical outcome to anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapy in patients with KRAS WT metastatic colorectal cancer. Although there is extensive literature suggesting the role of shelterin and telomerase, not much literature exists that describes the role of EGFR and KRAS pathway in regulating TL. This detailed review focuses on an insight into various components, including proteins, enzymes and transcription factors, interlinking between EGFR pathways and telomerase that regulate TL.

Original languageEnglish (US)
Pages (from-to)550-558
Number of pages9
JournalGenes and Cancer
Volume8
Issue number5-6
DOIs
StatePublished - May 1 2017

Fingerprint

Telomere
Epidermal Growth Factor Receptor
Telomerase
Neoplasms
Colorectal Neoplasms
Proteins
Transcription Factors
Chromosomes
Biomarkers
Monoclonal Antibodies
Enzymes
Therapeutics

Keywords

  • Biomarker identification
  • Colorectal cancer
  • EGFR pathways/signaling
  • Telomerase
  • Telomere length

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

@article{d291f38b668640069e4a9c03fbe3caeb,
title = "Telomere length regulation through epidermal growth factor receptor signaling in cancer",
abstract = "Length of the telomere (TL), a structure at the tip of chromosome that protects and ensures stability, is determined by multi-protein complexes such as telosome/ shelterin and telomerase. Earlier studies from our laboratory show that longer TL has potential to be positive predictive biomarker of clinical outcome to anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapy in patients with KRAS WT metastatic colorectal cancer. Although there is extensive literature suggesting the role of shelterin and telomerase, not much literature exists that describes the role of EGFR and KRAS pathway in regulating TL. This detailed review focuses on an insight into various components, including proteins, enzymes and transcription factors, interlinking between EGFR pathways and telomerase that regulate TL.",
keywords = "Biomarker identification, Colorectal cancer, EGFR pathways/signaling, Telomerase, Telomere length",
author = "Augustine, {Titto A.} and Radhashree Maitra and Sanjay Goel",
year = "2017",
month = "5",
day = "1",
doi = "10.18632/genesandcancer.140",
language = "English (US)",
volume = "8",
pages = "550--558",
journal = "Genes and Cancer",
issn = "1947-6019",
publisher = "SAGE Publications Inc.",
number = "5-6",

}

TY - JOUR

T1 - Telomere length regulation through epidermal growth factor receptor signaling in cancer

AU - Augustine, Titto A.

AU - Maitra, Radhashree

AU - Goel, Sanjay

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Length of the telomere (TL), a structure at the tip of chromosome that protects and ensures stability, is determined by multi-protein complexes such as telosome/ shelterin and telomerase. Earlier studies from our laboratory show that longer TL has potential to be positive predictive biomarker of clinical outcome to anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapy in patients with KRAS WT metastatic colorectal cancer. Although there is extensive literature suggesting the role of shelterin and telomerase, not much literature exists that describes the role of EGFR and KRAS pathway in regulating TL. This detailed review focuses on an insight into various components, including proteins, enzymes and transcription factors, interlinking between EGFR pathways and telomerase that regulate TL.

AB - Length of the telomere (TL), a structure at the tip of chromosome that protects and ensures stability, is determined by multi-protein complexes such as telosome/ shelterin and telomerase. Earlier studies from our laboratory show that longer TL has potential to be positive predictive biomarker of clinical outcome to anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapy in patients with KRAS WT metastatic colorectal cancer. Although there is extensive literature suggesting the role of shelterin and telomerase, not much literature exists that describes the role of EGFR and KRAS pathway in regulating TL. This detailed review focuses on an insight into various components, including proteins, enzymes and transcription factors, interlinking between EGFR pathways and telomerase that regulate TL.

KW - Biomarker identification

KW - Colorectal cancer

KW - EGFR pathways/signaling

KW - Telomerase

KW - Telomere length

UR - http://www.scopus.com/inward/record.url?scp=85041918627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041918627&partnerID=8YFLogxK

U2 - 10.18632/genesandcancer.140

DO - 10.18632/genesandcancer.140

M3 - Article

VL - 8

SP - 550

EP - 558

JO - Genes and Cancer

JF - Genes and Cancer

SN - 1947-6019

IS - 5-6

ER -