Telomere length regulation through epidermal growth factor receptor signaling in cancer

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Length of the telomere (TL), a structure at the tip of chromosome that protects and ensures stability, is determined by multi-protein complexes such as telosome/ shelterin and telomerase. Earlier studies from our laboratory show that longer TL has potential to be positive predictive biomarker of clinical outcome to anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapy in patients with KRAS WT metastatic colorectal cancer. Although there is extensive literature suggesting the role of shelterin and telomerase, not much literature exists that describes the role of EGFR and KRAS pathway in regulating TL. This detailed review focuses on an insight into various components, including proteins, enzymes and transcription factors, interlinking between EGFR pathways and telomerase that regulate TL.

Original languageEnglish (US)
Pages (from-to)550-558
Number of pages9
JournalGenes and Cancer
Volume8
Issue number5-6
DOIs
StatePublished - May 2017

Keywords

  • Biomarker identification
  • Colorectal cancer
  • EGFR pathways/signaling
  • Telomerase
  • Telomere length

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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