Telomere length in white blood cell DNA and lung cancer: A pooled analysis of three prospective cohorts

Wei Jie Seow, Richard M. Cawthon, Mark P. Purdue, Wei Hu, Yu Tang Gao, Wen Yi Huang, Stephanie J. Weinstein, Bu Tian Ji, Jarmo Virtamo, Howard D. Hosgood, Bryan A. Bassig, Xiao Ou Shu, Qiuyin Cai, Yong Bing Xiang, Shen Min, Wong Ho Chow, Sonja I. Berndt, Christopher Kim, Unhee Lim, Demetrius AlbanesNeil E. Caporaso, Stephen Chanock, Wei Zheng, Nathaniel Rothman, Qing Lan

Research output: Contribution to journalArticle

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Abstract

We investigated the relationship between telomere length and lung cancer in a pooled analysis from three prospective cohort studies: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, conducted among men and women in the United States, and previously published data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Trial conducted among male smokers in Finland, and the Shanghai Women's Health Study (SWHS), which is comprised primarily of never-smokers. The pooled population included 847 cases and 847 controls matched by study, age, and sex. Leukocyte telomere length was measured by a monochrome multiplex qPCR assay. We used conditional logistic regression models to calculate ORs and their 95% confidence intervals (CI) for the association between telomere length and lung cancer risk, adjusted for age and pack-years of smoking. Longer telomere length was associated with increased lung cancer risk in the pooled analysis [OR (95% CI) by quartile: 1.00; 1.24 (0.90-1.71); 1.27 (0.91-1.78); and 1.86 (1.33-2.62); P trend = 0.000022]. Findings were consistent across the three cohorts and strongest for subjects with very long telomere length, i.e., lung cancer risks for telomere length [OR (95% CI)] in the upper half of the fourth quartile were 2.41 (1.28-4.52), 2.16 (1.11-4.23), and 3.02(1.39-6.58) for the PLCO trial, the ATBC trial, and the SWHS, respectively. In addition, the association persisted among cases diagnosed more than 6 years after blood collection and was particularly evident for female adenocarcinoma cases. Telomere length in white blood cell DNA may be a biomarker of future increased risk of lung cancer in diverse populations.

Original languageEnglish (US)
Pages (from-to)4090-4098
Number of pages9
JournalCancer Research
Volume74
Issue number15
DOIs
StatePublished - Aug 1 2014

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Telomere
Lung Neoplasms
Leukocytes
DNA
beta Carotene
alpha-Tocopherol
Women's Health
Confidence Intervals
Logistic Models
Finland
Early Detection of Cancer
Ovarian Neoplasms
Population
Case-Control Studies
Prostate
Colorectal Neoplasms
Neoplasms
Prostatic Neoplasms
Adenocarcinoma
Cohort Studies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Seow, W. J., Cawthon, R. M., Purdue, M. P., Hu, W., Gao, Y. T., Huang, W. Y., ... Lan, Q. (2014). Telomere length in white blood cell DNA and lung cancer: A pooled analysis of three prospective cohorts. Cancer Research, 74(15), 4090-4098. https://doi.org/10.1158/0008-5472.CAN-14-0459

Telomere length in white blood cell DNA and lung cancer : A pooled analysis of three prospective cohorts. / Seow, Wei Jie; Cawthon, Richard M.; Purdue, Mark P.; Hu, Wei; Gao, Yu Tang; Huang, Wen Yi; Weinstein, Stephanie J.; Ji, Bu Tian; Virtamo, Jarmo; Hosgood, Howard D.; Bassig, Bryan A.; Shu, Xiao Ou; Cai, Qiuyin; Xiang, Yong Bing; Min, Shen; Chow, Wong Ho; Berndt, Sonja I.; Kim, Christopher; Lim, Unhee; Albanes, Demetrius; Caporaso, Neil E.; Chanock, Stephen; Zheng, Wei; Rothman, Nathaniel; Lan, Qing.

In: Cancer Research, Vol. 74, No. 15, 01.08.2014, p. 4090-4098.

Research output: Contribution to journalArticle

Seow, WJ, Cawthon, RM, Purdue, MP, Hu, W, Gao, YT, Huang, WY, Weinstein, SJ, Ji, BT, Virtamo, J, Hosgood, HD, Bassig, BA, Shu, XO, Cai, Q, Xiang, YB, Min, S, Chow, WH, Berndt, SI, Kim, C, Lim, U, Albanes, D, Caporaso, NE, Chanock, S, Zheng, W, Rothman, N & Lan, Q 2014, 'Telomere length in white blood cell DNA and lung cancer: A pooled analysis of three prospective cohorts', Cancer Research, vol. 74, no. 15, pp. 4090-4098. https://doi.org/10.1158/0008-5472.CAN-14-0459
Seow, Wei Jie ; Cawthon, Richard M. ; Purdue, Mark P. ; Hu, Wei ; Gao, Yu Tang ; Huang, Wen Yi ; Weinstein, Stephanie J. ; Ji, Bu Tian ; Virtamo, Jarmo ; Hosgood, Howard D. ; Bassig, Bryan A. ; Shu, Xiao Ou ; Cai, Qiuyin ; Xiang, Yong Bing ; Min, Shen ; Chow, Wong Ho ; Berndt, Sonja I. ; Kim, Christopher ; Lim, Unhee ; Albanes, Demetrius ; Caporaso, Neil E. ; Chanock, Stephen ; Zheng, Wei ; Rothman, Nathaniel ; Lan, Qing. / Telomere length in white blood cell DNA and lung cancer : A pooled analysis of three prospective cohorts. In: Cancer Research. 2014 ; Vol. 74, No. 15. pp. 4090-4098.
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AU - Hu, Wei

AU - Gao, Yu Tang

AU - Huang, Wen Yi

AU - Weinstein, Stephanie J.

AU - Ji, Bu Tian

AU - Virtamo, Jarmo

AU - Hosgood, Howard D.

AU - Bassig, Bryan A.

AU - Shu, Xiao Ou

AU - Cai, Qiuyin

AU - Xiang, Yong Bing

AU - Min, Shen

AU - Chow, Wong Ho

AU - Berndt, Sonja I.

AU - Kim, Christopher

AU - Lim, Unhee

AU - Albanes, Demetrius

AU - Caporaso, Neil E.

AU - Chanock, Stephen

AU - Zheng, Wei

AU - Rothman, Nathaniel

AU - Lan, Qing

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