Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men

Qibin Qi, Yanping Li, Andrea K. Chomistek, Jae H. Kang, Gary C. Curhan, Louis R. Pasquale, Walter C. Willett, Eric B. Rimm, Frank B. Hu, Lu Qi

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Background-Previous studies on gene-lifestyle interaction and obesity have focused mostly on the FTO gene and physical activity, whereas little attention has been paid to sedentary behavior as indicated by television (TV) watching. Methods and Results-We analyzed interactions between TV watching, leisure time physical activity, and genetic predisposition in relation to body mass index (BMI) in 7740 women and 4564 men from 2 prospective cohorts: The Nurses Health Study and the Health Professionals Follow-up Study. Data on physical activity and TV watching were collected 2 years before assessment of BMI. A weighted genetic risk score was calculated on the basis of 32 established BMI-associated variants. In both women and men, the genetic associations with BMI strengthened with increased hours of TV watching. An increment of 10 points in the weighted genetic risk score was associated with 0.8 (SE, 0.4), 0.8 (SE, 0.2), 1.4 (SE, 0.2), 1.5 (SE, 0.2), and 3.4 (SE, 1.0) kg/m higher BMI across the 5 categories of TV watching (0-1, 2-5, 6-20, 21-40, and >40 h/wk; P for interaction=0.001). In contrast, the genetic association with BMI weakened with increased levels of physical activity. An increment of 10 points in the weighted genetic risk score was associated with 1.5 (SE, 0.2), 1.3 (SE, 0.2), 1.2 (SE, 0.2), 1.2 (SE, 0.2), and 0.8 (SE, 0.2) kg/m higher BMI across the quintiles of physical activity. The interactions of TV watching and physical activity with genetic predisposition in relation to BMI were independent of each other. Conclusions-A sedentary lifestyle, indicated by prolonged TV watching, may accentuate the predisposition to elevated adiposity, whereas greater leisure time physical activity may attenuate the genetic association.

Original languageEnglish (US)
Pages (from-to)1821-1827
Number of pages7
JournalCirculation
Volume126
Issue number15
DOIs
StatePublished - Oct 9 2012
Externally publishedYes

Fingerprint

Leisure Activities
Television
Genetic Predisposition to Disease
Body Mass Index
Exercise
Sedentary Lifestyle
Adiposity
Health
Genes
Life Style
Obesity
Nurses

Keywords

  • body mass index
  • genetics
  • physical activity
  • sedentary lifestyle
  • television viewing

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men. / Qi, Qibin; Li, Yanping; Chomistek, Andrea K.; Kang, Jae H.; Curhan, Gary C.; Pasquale, Louis R.; Willett, Walter C.; Rimm, Eric B.; Hu, Frank B.; Qi, Lu.

In: Circulation, Vol. 126, No. 15, 09.10.2012, p. 1821-1827.

Research output: Contribution to journalArticle

Qi, Q, Li, Y, Chomistek, AK, Kang, JH, Curhan, GC, Pasquale, LR, Willett, WC, Rimm, EB, Hu, FB & Qi, L 2012, 'Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men', Circulation, vol. 126, no. 15, pp. 1821-1827. https://doi.org/10.1161/CIRCULATIONAHA.112.098061
Qi, Qibin ; Li, Yanping ; Chomistek, Andrea K. ; Kang, Jae H. ; Curhan, Gary C. ; Pasquale, Louis R. ; Willett, Walter C. ; Rimm, Eric B. ; Hu, Frank B. ; Qi, Lu. / Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men. In: Circulation. 2012 ; Vol. 126, No. 15. pp. 1821-1827.
@article{10bf8abee35842af9526b01838f3d41d,
title = "Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men",
abstract = "Background-Previous studies on gene-lifestyle interaction and obesity have focused mostly on the FTO gene and physical activity, whereas little attention has been paid to sedentary behavior as indicated by television (TV) watching. Methods and Results-We analyzed interactions between TV watching, leisure time physical activity, and genetic predisposition in relation to body mass index (BMI) in 7740 women and 4564 men from 2 prospective cohorts: The Nurses Health Study and the Health Professionals Follow-up Study. Data on physical activity and TV watching were collected 2 years before assessment of BMI. A weighted genetic risk score was calculated on the basis of 32 established BMI-associated variants. In both women and men, the genetic associations with BMI strengthened with increased hours of TV watching. An increment of 10 points in the weighted genetic risk score was associated with 0.8 (SE, 0.4), 0.8 (SE, 0.2), 1.4 (SE, 0.2), 1.5 (SE, 0.2), and 3.4 (SE, 1.0) kg/m higher BMI across the 5 categories of TV watching (0-1, 2-5, 6-20, 21-40, and >40 h/wk; P for interaction=0.001). In contrast, the genetic association with BMI weakened with increased levels of physical activity. An increment of 10 points in the weighted genetic risk score was associated with 1.5 (SE, 0.2), 1.3 (SE, 0.2), 1.2 (SE, 0.2), 1.2 (SE, 0.2), and 0.8 (SE, 0.2) kg/m higher BMI across the quintiles of physical activity. The interactions of TV watching and physical activity with genetic predisposition in relation to BMI were independent of each other. Conclusions-A sedentary lifestyle, indicated by prolonged TV watching, may accentuate the predisposition to elevated adiposity, whereas greater leisure time physical activity may attenuate the genetic association.",
keywords = "body mass index, genetics, physical activity, sedentary lifestyle, television viewing",
author = "Qibin Qi and Yanping Li and Chomistek, {Andrea K.} and Kang, {Jae H.} and Curhan, {Gary C.} and Pasquale, {Louis R.} and Willett, {Walter C.} and Rimm, {Eric B.} and Hu, {Frank B.} and Lu Qi",
year = "2012",
month = "10",
day = "9",
doi = "10.1161/CIRCULATIONAHA.112.098061",
language = "English (US)",
volume = "126",
pages = "1821--1827",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "15",

}

TY - JOUR

T1 - Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men

AU - Qi, Qibin

AU - Li, Yanping

AU - Chomistek, Andrea K.

AU - Kang, Jae H.

AU - Curhan, Gary C.

AU - Pasquale, Louis R.

AU - Willett, Walter C.

AU - Rimm, Eric B.

AU - Hu, Frank B.

AU - Qi, Lu

PY - 2012/10/9

Y1 - 2012/10/9

N2 - Background-Previous studies on gene-lifestyle interaction and obesity have focused mostly on the FTO gene and physical activity, whereas little attention has been paid to sedentary behavior as indicated by television (TV) watching. Methods and Results-We analyzed interactions between TV watching, leisure time physical activity, and genetic predisposition in relation to body mass index (BMI) in 7740 women and 4564 men from 2 prospective cohorts: The Nurses Health Study and the Health Professionals Follow-up Study. Data on physical activity and TV watching were collected 2 years before assessment of BMI. A weighted genetic risk score was calculated on the basis of 32 established BMI-associated variants. In both women and men, the genetic associations with BMI strengthened with increased hours of TV watching. An increment of 10 points in the weighted genetic risk score was associated with 0.8 (SE, 0.4), 0.8 (SE, 0.2), 1.4 (SE, 0.2), 1.5 (SE, 0.2), and 3.4 (SE, 1.0) kg/m higher BMI across the 5 categories of TV watching (0-1, 2-5, 6-20, 21-40, and >40 h/wk; P for interaction=0.001). In contrast, the genetic association with BMI weakened with increased levels of physical activity. An increment of 10 points in the weighted genetic risk score was associated with 1.5 (SE, 0.2), 1.3 (SE, 0.2), 1.2 (SE, 0.2), 1.2 (SE, 0.2), and 0.8 (SE, 0.2) kg/m higher BMI across the quintiles of physical activity. The interactions of TV watching and physical activity with genetic predisposition in relation to BMI were independent of each other. Conclusions-A sedentary lifestyle, indicated by prolonged TV watching, may accentuate the predisposition to elevated adiposity, whereas greater leisure time physical activity may attenuate the genetic association.

AB - Background-Previous studies on gene-lifestyle interaction and obesity have focused mostly on the FTO gene and physical activity, whereas little attention has been paid to sedentary behavior as indicated by television (TV) watching. Methods and Results-We analyzed interactions between TV watching, leisure time physical activity, and genetic predisposition in relation to body mass index (BMI) in 7740 women and 4564 men from 2 prospective cohorts: The Nurses Health Study and the Health Professionals Follow-up Study. Data on physical activity and TV watching were collected 2 years before assessment of BMI. A weighted genetic risk score was calculated on the basis of 32 established BMI-associated variants. In both women and men, the genetic associations with BMI strengthened with increased hours of TV watching. An increment of 10 points in the weighted genetic risk score was associated with 0.8 (SE, 0.4), 0.8 (SE, 0.2), 1.4 (SE, 0.2), 1.5 (SE, 0.2), and 3.4 (SE, 1.0) kg/m higher BMI across the 5 categories of TV watching (0-1, 2-5, 6-20, 21-40, and >40 h/wk; P for interaction=0.001). In contrast, the genetic association with BMI weakened with increased levels of physical activity. An increment of 10 points in the weighted genetic risk score was associated with 1.5 (SE, 0.2), 1.3 (SE, 0.2), 1.2 (SE, 0.2), 1.2 (SE, 0.2), and 0.8 (SE, 0.2) kg/m higher BMI across the quintiles of physical activity. The interactions of TV watching and physical activity with genetic predisposition in relation to BMI were independent of each other. Conclusions-A sedentary lifestyle, indicated by prolonged TV watching, may accentuate the predisposition to elevated adiposity, whereas greater leisure time physical activity may attenuate the genetic association.

KW - body mass index

KW - genetics

KW - physical activity

KW - sedentary lifestyle

KW - television viewing

UR - http://www.scopus.com/inward/record.url?scp=84867261218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867261218&partnerID=8YFLogxK

U2 - 10.1161/CIRCULATIONAHA.112.098061

DO - 10.1161/CIRCULATIONAHA.112.098061

M3 - Article

C2 - 22949498

AN - SCOPUS:84867261218

VL - 126

SP - 1821

EP - 1827

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 15

ER -