Taxol produces a predominantly sensory neuropathy

Richard B. Lipton, S. C. Apfel, J. P. Dutcher, R. Rosenberg, J. Kaplan, A. Berger, Avi Israel Einzig, P. Wiernik, H. H. Schaumburg

Research output: Contribution to journalArticle

240 Citations (Scopus)

Abstract

Taxol, a plant alkaloid with promise as an antineoplastic agent, produced a predominantly sensory neuropathy in 16 of 60 patients treated in two phase I trials. This neuropathy occurred only at taxol doses greater than 200 mg/m2. Symptoms typically started 1 to 3 days following treatment, beginning in the hands and feet simultaneously in most patients. Electrophysiologic data suggests both axonal degeneration and demyelination. This previously undefined neurotoxic neuropathy most likely results from taxol’s unique ability to produce microtubule aggregation in dorsal root ganglion cells, axons, and Schwann cells.

Original languageEnglish (US)
Pages (from-to)368-373
Number of pages6
JournalNeurology
Volume39
Issue number3
StatePublished - 1989

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Paclitaxel
Schwann Cells
Spinal Ganglia
Demyelinating Diseases
Alkaloids
Microtubules
Antineoplastic Agents
Axons
Foot
Hand
Cells
Therapeutics
Degeneration
Dose

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Lipton, R. B., Apfel, S. C., Dutcher, J. P., Rosenberg, R., Kaplan, J., Berger, A., ... Schaumburg, H. H. (1989). Taxol produces a predominantly sensory neuropathy. Neurology, 39(3), 368-373.

Taxol produces a predominantly sensory neuropathy. / Lipton, Richard B.; Apfel, S. C.; Dutcher, J. P.; Rosenberg, R.; Kaplan, J.; Berger, A.; Einzig, Avi Israel; Wiernik, P.; Schaumburg, H. H.

In: Neurology, Vol. 39, No. 3, 1989, p. 368-373.

Research output: Contribution to journalArticle

Lipton, RB, Apfel, SC, Dutcher, JP, Rosenberg, R, Kaplan, J, Berger, A, Einzig, AI, Wiernik, P & Schaumburg, HH 1989, 'Taxol produces a predominantly sensory neuropathy', Neurology, vol. 39, no. 3, pp. 368-373.
Lipton RB, Apfel SC, Dutcher JP, Rosenberg R, Kaplan J, Berger A et al. Taxol produces a predominantly sensory neuropathy. Neurology. 1989;39(3):368-373.
Lipton, Richard B. ; Apfel, S. C. ; Dutcher, J. P. ; Rosenberg, R. ; Kaplan, J. ; Berger, A. ; Einzig, Avi Israel ; Wiernik, P. ; Schaumburg, H. H. / Taxol produces a predominantly sensory neuropathy. In: Neurology. 1989 ; Vol. 39, No. 3. pp. 368-373.
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