Taxol

mechanisms of action and resistance.

Susan Band Horwitz, D. Cohen, S. Rao, I. Ringel, H. J. Shen, Chia-Ping H. Yang

Research output: Contribution to journalArticle

285 Citations (Scopus)

Abstract

Information on the mechanisms of action and of resistance to Taxol, as well as new data from our laboratory on the promoter regions of the genes that encode P-glycoprotein in a murine Taxol-resistant cell line, is discussed. Taxol induces the formation of stable bundles of microtubules, thereby interfering with the normal function of cellular microtubules. The drug can induce the multidrug-resistance (MDR) phenotype that includes the overproduction of P-glycoprotein, a membrane glycoprotein that acts as a drug efflux pump. In human tumors resistant to Taxol, P-glycoprotein could be responsible for maintaining the drug below cytotoxic levels. Analyses of the MDR promoters that are involved in P-glycoprotein expression and overproduction revealed an interesting recombination event in a Taxol-resistant cell line. As an important new clinical agent for the treatment of malignancies, Taxol requires further mechanistic investigations at the preclinical level.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalJournal of the National Cancer Institute. Monographs
Issue number15
StatePublished - 1993

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Paclitaxel
P-Glycoprotein
Multiple Drug Resistance
Microtubules
Pharmaceutical Preparations
Cell Line
Membrane Glycoproteins
Genetic Promoter Regions
Genetic Recombination
Neoplasms
Phenotype
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Taxol : mechanisms of action and resistance. / Band Horwitz, Susan; Cohen, D.; Rao, S.; Ringel, I.; Shen, H. J.; Yang, Chia-Ping H.

In: Journal of the National Cancer Institute. Monographs, No. 15, 1993, p. 55-61.

Research output: Contribution to journalArticle

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