Taxol-induced neuropathy: short-term effects of local injection

Matias Röyttä, Susan Band Horwitz, Cedric S. Raine

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Taxol, a compound that enhances microtubule polymerization, was injected locally into the sciatic nerve of the rat and its effects examined by electron microscopy up to 21 days postinjection. The drug did not have a degenerative effect upon the P.N.S. but caused a slow accumulation of microtubules, first seen within Schwann cells and shortly thereafter, in axons. Within Schwann cells, microtubule aggregates evolved at the expense of rough endoplasmic reticulum (ER) and microtubule arrays were frequently encountered in relationship to smooth ER cisterns. Arrested mitoses were seen, there was no proliferation of Schwann cells and long stretches of axon were naked. Within axons, microtubules predominated over intermediate filaments and displayed a tendency to cluster around mitochondria. The lesion appeared to be focal and to be related to a local axonal stasis. These experiments provide yet another tool for the examination of Schwann cell-axon interactions.

Original languageEnglish (US)
Pages (from-to)685-701
Number of pages17
JournalJournal of Neurocytology
Volume13
Issue number5
DOIs
StatePublished - Oct 1984

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Paclitaxel
Microtubules
Schwann Cells
Axons
Injections
Smooth Endoplasmic Reticulum
Intermediate Filaments
Rough Endoplasmic Reticulum
Sciatic Nerve
Mitosis
Cell Communication
Polymerization
Electron Microscopy
Mitochondria
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)
  • Histology
  • Anatomy
  • Cell Biology

Cite this

Taxol-induced neuropathy : short-term effects of local injection. / Röyttä, Matias; Band Horwitz, Susan; Raine, Cedric S.

In: Journal of Neurocytology, Vol. 13, No. 5, 10.1984, p. 685-701.

Research output: Contribution to journalArticle

Röyttä, Matias ; Band Horwitz, Susan ; Raine, Cedric S. / Taxol-induced neuropathy : short-term effects of local injection. In: Journal of Neurocytology. 1984 ; Vol. 13, No. 5. pp. 685-701.
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