Taxol effects on GLIA in organotypic mouse spinal cord-DRG cultures

E. B. Masurovsky, E. R. Peterson, S. M. Crain, S. B. Horwitz

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Exposure of organotypic mouse spinal cord-dorsal root ganglion cultures to 1-2 μM taxol for up to 6 days results in a remarkable increase in cytoplasmic microtubules in differentiated oligodendroglia. In contrast, there is a notably smaller change in the microtubule compliment of astroglia. This suggests that the regulatory and/or synthetic systems for tubulin in these glial types may differ, and that oligodendroglia appear more responsive to modulation in the levels of tubulin subunits as a result of the action of taxol.

Original languageEnglish (US)
Pages (from-to)539-546
Number of pages8
JournalCell Biology International Reports
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 1985

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ASJC Scopus subject areas

  • Cell Biology

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