Taxol effects on GLIA in organotypic mouse spinal cord-DRG cultures

E. B. Masurovsky, E. R. Peterson, S. M. Crain, Susan Band Horwitz

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Exposure of organotypic mouse spinal cord-dorsal root ganglion cultures to 1-2 μM taxol for up to 6 days results in a remarkable increase in cytoplasmic microtubules in differentiated oligodendroglia. In contrast, there is a notably smaller change in the microtubule compliment of astroglia. This suggests that the regulatory and/or synthetic systems for tubulin in these glial types may differ, and that oligodendroglia appear more responsive to modulation in the levels of tubulin subunits as a result of the action of taxol.

Original languageEnglish (US)
Pages (from-to)539-546
Number of pages8
JournalCell Biology International Reports
Volume9
Issue number6
DOIs
StatePublished - 1985

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Diagnosis-Related Groups
Oligodendroglia
Tubulin
Paclitaxel
Microtubules
Spinal Cord
Spinal Ganglia
Neuroglia
Astrocytes

ASJC Scopus subject areas

  • Cell Biology

Cite this

Taxol effects on GLIA in organotypic mouse spinal cord-DRG cultures. / Masurovsky, E. B.; Peterson, E. R.; Crain, S. M.; Band Horwitz, Susan.

In: Cell Biology International Reports, Vol. 9, No. 6, 1985, p. 539-546.

Research output: Contribution to journalArticle

Masurovsky, E. B. ; Peterson, E. R. ; Crain, S. M. ; Band Horwitz, Susan. / Taxol effects on GLIA in organotypic mouse spinal cord-DRG cultures. In: Cell Biology International Reports. 1985 ; Vol. 9, No. 6. pp. 539-546.
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