Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes

Xiaobo Li, Hongbao Yang, Hao Sun, Runze Lu, Chengcheng Zhang, Na Gao, Qingtao Meng, Shenshen Wu, Susanna Wang, Michael Aschner, Jiong Wu, Boping Tang, Aihua Gu, Steve A. Kay, Rui Chen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) has been linked to particulate matter (PM) exposure. Using transcriptomic analysis, we demonstrate that diesel exhaust particles, one of the major sources of particulate emission, down-regulated genes located in mitochondrial complexes I and V and induced experimental COPD in a mouse model. 1-Nitropyrene was identified as a major toxic component of PM-induced COPD. In the panel study, COPD patients were found to be more susceptible to PM than individuals with normal lung function due to an increased inflammatory response. Mechanistically, exposure to PM in human bronchial epithelial cells led to a decline in CCAAT/enhancer-binding protein alpha (C/EBPα), which triggered aberrant expression of NADH dehydrogenase genes and ultimately led to enhanced autophagy. ATG7-deficient mice, which have lower autophagy rates, were protected from PM-induced experimental COPD. Using metabolomics analysis, we further established that treatment with taurine and 3-methyladenine completely restored mitochondrial gene expression levels, thereby ameliorating the PM-induced emphysema. Our studies suggest a potential therapeutic intervention for the C/EBPα/mitochondria/autophagy axis in PM-induced COPD.

Original languageEnglish (US)
Pages (from-to)E9655-E9664
JournalProceedings of the National Academy of Sciences of the United States of America
Volume114
Issue number45
DOIs
StatePublished - Nov 7 2017

Fingerprint

NADH Dehydrogenase
Particulate Matter
Taurine
Emphysema
Chronic Obstructive Pulmonary Disease
Autophagy
Genes
CCAAT-Enhancer-Binding Protein-alpha
1-nitropyrene
Vehicle Emissions
Metabolomics
Mitochondrial Genes
Poisons
Mitochondria
Epithelial Cells
Gene Expression
Lung
Therapeutics

Keywords

  • Autophagy
  • Chronic obstructive pulmonary disease
  • Mitochondria
  • Particulate matter
  • Taurine

ASJC Scopus subject areas

  • General

Cite this

Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes. / Li, Xiaobo; Yang, Hongbao; Sun, Hao; Lu, Runze; Zhang, Chengcheng; Gao, Na; Meng, Qingtao; Wu, Shenshen; Wang, Susanna; Aschner, Michael; Wu, Jiong; Tang, Boping; Gu, Aihua; Kay, Steve A.; Chen, Rui.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 45, 07.11.2017, p. E9655-E9664.

Research output: Contribution to journalArticle

Li, X, Yang, H, Sun, H, Lu, R, Zhang, C, Gao, N, Meng, Q, Wu, S, Wang, S, Aschner, M, Wu, J, Tang, B, Gu, A, Kay, SA & Chen, R 2017, 'Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 45, pp. E9655-E9664. https://doi.org/10.1073/pnas.1712465114
Li, Xiaobo ; Yang, Hongbao ; Sun, Hao ; Lu, Runze ; Zhang, Chengcheng ; Gao, Na ; Meng, Qingtao ; Wu, Shenshen ; Wang, Susanna ; Aschner, Michael ; Wu, Jiong ; Tang, Boping ; Gu, Aihua ; Kay, Steve A. ; Chen, Rui. / Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes. In: Proceedings of the National Academy of Sciences of the United States of America. 2017 ; Vol. 114, No. 45. pp. E9655-E9664.
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