Targeting the tumor microenvironment

Paraic A. Kenny, Genee Y. Lee, Mina J. Bissell

Research output: Contribution to journalReview article

149 Scopus citations

Abstract

Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the "druggable" targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.

Original languageEnglish (US)
Pages (from-to)3468-3474
Number of pages7
JournalFrontiers in Bioscience
Volume12
Issue number9
DOIs
StatePublished - May 1 2007

Keywords

  • Cancer
  • Cancer therapy
  • Review
  • Stromal-epithelial interaction
  • Tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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