Abstract
Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.
Original language | English (US) |
---|---|
Journal | OncoImmunology |
Volume | 4 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2 2015 |
Fingerprint
Keywords
- c-di-GMP
- IL-12
- Listeria-Mage-b
- metastatic breast cancer
- STING ligand
ASJC Scopus subject areas
- Immunology and Allergy
- Oncology
- Immunology
Cite this
Targeting STING pathways for the treatment of cancer. / Gravekamp, Claudia; Chandra, Dinesh.
In: OncoImmunology, Vol. 4, No. 12, 02.12.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Targeting STING pathways for the treatment of cancer
AU - Gravekamp, Claudia
AU - Chandra, Dinesh
PY - 2015/12/2
Y1 - 2015/12/2
N2 - Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.
AB - Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.
KW - c-di-GMP
KW - IL-12
KW - Listeria-Mage-b
KW - metastatic breast cancer
KW - STING ligand
UR - http://www.scopus.com/inward/record.url?scp=84944522894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84944522894&partnerID=8YFLogxK
U2 - 10.4161/2162402X.2014.988463
DO - 10.4161/2162402X.2014.988463
M3 - Article
AN - SCOPUS:84944522894
VL - 4
JO - OncoImmunology
JF - OncoImmunology
SN - 2162-4011
IS - 12
ER -