Targeting STING pathways for the treatment of cancer

Claudia Gravekamp; Dinesh Chandra

doi:10.4161/2162402X.2014.988463

Targeting STING pathways for the treatment of cancer

Claudia Gravekamp, Dinesh Chandra

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.

Original language	English (US)
Journal	OncoImmunology
Volume	4
Issue number	12
DOIs	https://doi.org/10.4161/2162402X.2014.988463
State	Published - Dec 2 2015

Keywords

IL-12
Listeria-Mage-b
STING ligand
c-di-GMP
metastatic breast cancer

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

Access to Document

10.4161/2162402X.2014.988463

Fingerprint Dive into the research topics of 'Targeting STING pathways for the treatment of cancer'. Together they form a unique fingerprint.

Cite this

@article{433a06befaa043c8b7a9b74b10cbc7d5,

title = "Targeting STING pathways for the treatment of cancer",

abstract = "Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.",

keywords = "IL-12, Listeria-Mage-b, STING ligand, c-di-GMP, metastatic breast cancer",

author = "Claudia Gravekamp and Dinesh Chandra",

year = "2015",

month = dec,

day = "2",

doi = "10.4161/2162402X.2014.988463",

language = "English (US)",

volume = "4",

journal = "OncoImmunology",

issn = "2162-4011",

publisher = "Landes Bioscience",

number = "12",

}

TY - JOUR

T1 - Targeting STING pathways for the treatment of cancer

AU - Gravekamp, Claudia

AU - Chandra, Dinesh

PY - 2015/12/2

Y1 - 2015/12/2

N2 - Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.

AB - Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.

KW - IL-12

KW - Listeria-Mage-b

KW - STING ligand

KW - c-di-GMP

KW - metastatic breast cancer

UR - http://www.scopus.com/inward/record.url?scp=84944522894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944522894&partnerID=8YFLogxK

U2 - 10.4161/2162402X.2014.988463

DO - 10.4161/2162402X.2014.988463

M3 - Article

AN - SCOPUS:84944522894

VL - 4

JO - OncoImmunology

JF - OncoImmunology

SN - 2162-4011

IS - 12

ER -

Targeting STING pathways for the treatment of cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this