Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.
|Original language||English (US)|
|State||Published - Dec 2 2015|
- STING ligand
- metastatic breast cancer
ASJC Scopus subject areas
- Immunology and Allergy