Targeting STING pathways for the treatment of cancer

Claudia Gravekamp; Dinesh Chandra

doi:10.4161/2162402X.2014.988463

Targeting STING pathways for the treatment of cancer

Claudia Gravekamp, Dinesh Chandra

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.

Original language	English (US)
Journal	OncoImmunology
Volume	4
Issue number	12
DOIs	https://doi.org/10.4161/2162402X.2014.988463
State	Published - Dec 2 2015

Keywords

IL-12
Listeria-Mage-b
STING ligand
c-di-GMP
metastatic breast cancer

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/2162402X.2014.988463

Cite this

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title = "Targeting STING pathways for the treatment of cancer",

abstract = "Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.",

keywords = "IL-12, Listeria-Mage-b, STING ligand, c-di-GMP, metastatic breast cancer",

author = "Claudia Gravekamp and Dinesh Chandra",

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AU - Chandra, Dinesh

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N2 - Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.

AB - Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.

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KW - STING ligand

KW - c-di-GMP

KW - metastatic breast cancer

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Targeting STING pathways for the treatment of cancer

Abstract

Keywords

ASJC Scopus subject areas

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