Targeting STING pathways for the treatment of cancer

Claudia Gravekamp, Dinesh Chandra

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.

Original languageEnglish (US)
JournalOncoImmunology
Volume4
Issue number12
DOIs
StatePublished - Dec 2 2015

Fingerprint

Interferons
Genes
Neoplasms
Vaccination
Cell Death
Breast Neoplasms
Neoplasm Metastasis
Ligands
Therapeutics
bis(3',5')-cyclic diguanylic acid

Keywords

  • c-di-GMP
  • IL-12
  • Listeria-Mage-b
  • metastatic breast cancer
  • STING ligand

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

Targeting STING pathways for the treatment of cancer. / Gravekamp, Claudia; Chandra, Dinesh.

In: OncoImmunology, Vol. 4, No. 12, 02.12.2015.

Research output: Contribution to journalArticle

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