TY - JOUR
T1 - Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease
AU - Grattagliano, Ignazio
AU - Montezinho, Liliana P.
AU - Oliveira, Paulo J.
AU - Frühbeck, Gema
AU - Gómez-Ambrosi, Javier
AU - Montecucco, Fabrizio
AU - Carbone, Federico
AU - Wieckowski, Mariusz R.
AU - Wang, David Q.H.
AU - Portincasa, Piero
N1 - Publisher Copyright:
© 2018
PY - 2019/2
Y1 - 2019/2
N2 - Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the excessive accumulation of triglycerides in hepatocytes. NAFLD is the most frequent chronic liver disease in developed countries, and is often associated with metabolic disorders such as obesity and type 2 diabetes. NAFLD definition encompasses a spectrum of chronic liver abnormalities, ranging from simple steatosis (NAFL), to steatohepatitis (NASH), significant liver fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD, therefore, represents a global public health issue. Mitochondrial dysfunction occurs in NAFLD, and contributes to the progression to the necro-inflammatory and fibrotic form (NASH). Disrupted mitochondrial function is associated with a decrease in the energy levels and impaired redox balance, and negatively affects cell survival by altering overall metabolism and subcellular trafficking. Such events reduce the tolerance of hepatocytes towards damaging hits, and favour the injurious effects of extra-cellular factors. Here, we discuss the role of mitochondria in NAFLD and focus on potential therapeutic approaches aimed at preserving mitochondrial function.
AB - Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the excessive accumulation of triglycerides in hepatocytes. NAFLD is the most frequent chronic liver disease in developed countries, and is often associated with metabolic disorders such as obesity and type 2 diabetes. NAFLD definition encompasses a spectrum of chronic liver abnormalities, ranging from simple steatosis (NAFL), to steatohepatitis (NASH), significant liver fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD, therefore, represents a global public health issue. Mitochondrial dysfunction occurs in NAFLD, and contributes to the progression to the necro-inflammatory and fibrotic form (NASH). Disrupted mitochondrial function is associated with a decrease in the energy levels and impaired redox balance, and negatively affects cell survival by altering overall metabolism and subcellular trafficking. Such events reduce the tolerance of hepatocytes towards damaging hits, and favour the injurious effects of extra-cellular factors. Here, we discuss the role of mitochondria in NAFLD and focus on potential therapeutic approaches aimed at preserving mitochondrial function.
KW - Fatty liver
KW - Mitochondria
KW - Nitrosative stress
KW - Nonalcoholic fatty liver disease
KW - Oxidative stress
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U2 - 10.1016/j.bcp.2018.11.020
DO - 10.1016/j.bcp.2018.11.020
M3 - Review article
C2 - 30508523
AN - SCOPUS:85058538556
SN - 0006-2952
VL - 160
SP - 34
EP - 45
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
ER -