Targeting metabotropic glutamate receptors in neuroimmune communication

C. Volpi, F. Fazio, F. Fallarino

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

l-Glutamate (l-Glu) is the principal excitatory neurotransmitter in the Central Nervous System (CNS), where it regulates cellular and synaptic activity, neuronal plasticity, cell survival and other relevant functions. Glutamatergic neurotransmission is complex and involves both ionotropic (ligand-gated ion channels; iGluRs) and metabotropic receptors (G-protein coupled receptors). Recent evidence suggests that glutamatergic receptors are also expressed by immune cells, regulating the degree of cell activation. In this review we primarily focus on mGluRs and their role in the crosstalk between the central nervous and immune systems during neuroinflammation.

Original languageEnglish (US)
Pages (from-to)501-506
Number of pages6
JournalNeuropharmacology
Volume63
Issue number4
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

Keywords

  • Metabotropic glutamate receptors
  • Neuroimmune communication
  • Neuroinflammation

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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