Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination

Brian W. Jones, Jennifer Deem, Thomas J. Younts, Michael Weisenhaus, Christina A. Sanford, Margaret C. Slack, Jenesa Chin, Daniela Nachmanson, Alex McKennon, Pablo E. Castillo, G. Stanley McKnight

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Protein Kinase A (PKA) mediates synaptic plasticity and is widely implicated in learning and memory. The hippocampal dentate gyrus (DG) is thought to be responsible for processing and encoding distinct contextual associations in response to highly similar inputs. The mossy fiber (MF) axons of the dentate granule cells convey strong excitatory drive to CA3 pyramidal neurons and express presynaptic, PKA-dependent forms of plasticity. Here, we demonstrate an essential role for the PKA anchoring protein, AKAP7, in mouse MF axons and terminals. Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of MF-CA3 LTP directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. Our results suggest that the AKAP7/PKA complex in the MF projections plays an essential role in synaptic plasticity and contextual memory formation.

Original languageEnglish (US)
Article numbere20695
JournaleLife
Volume5
Issue numberDECEMBER2016
DOIs
StatePublished - Dec 2 2016

Fingerprint

Cyclic AMP-Dependent Protein Kinases
Plasticity
Neuronal Plasticity
Fibers
Data storage equipment
Parahippocampal Gyrus
Pyramidal Cells
Dentate Gyrus
Presynaptic Terminals
Ablation
Neurons
Axons
Learning
Discrimination (Psychology)
Processing
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Jones, B. W., Deem, J., Younts, T. J., Weisenhaus, M., Sanford, C. A., Slack, M. C., ... McKnight, G. S. (2016). Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination. eLife, 5(DECEMBER2016), [e20695]. https://doi.org/10.7554/eLife.20695

Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination. / Jones, Brian W.; Deem, Jennifer; Younts, Thomas J.; Weisenhaus, Michael; Sanford, Christina A.; Slack, Margaret C.; Chin, Jenesa; Nachmanson, Daniela; McKennon, Alex; Castillo, Pablo E.; McKnight, G. Stanley.

In: eLife, Vol. 5, No. DECEMBER2016, e20695, 02.12.2016.

Research output: Contribution to journalArticle

Jones, BW, Deem, J, Younts, TJ, Weisenhaus, M, Sanford, CA, Slack, MC, Chin, J, Nachmanson, D, McKennon, A, Castillo, PE & McKnight, GS 2016, 'Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination', eLife, vol. 5, no. DECEMBER2016, e20695. https://doi.org/10.7554/eLife.20695
Jones BW, Deem J, Younts TJ, Weisenhaus M, Sanford CA, Slack MC et al. Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination. eLife. 2016 Dec 2;5(DECEMBER2016). e20695. https://doi.org/10.7554/eLife.20695
Jones, Brian W. ; Deem, Jennifer ; Younts, Thomas J. ; Weisenhaus, Michael ; Sanford, Christina A. ; Slack, Margaret C. ; Chin, Jenesa ; Nachmanson, Daniela ; McKennon, Alex ; Castillo, Pablo E. ; McKnight, G. Stanley. / Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination. In: eLife. 2016 ; Vol. 5, No. DECEMBER2016.
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