Tandem genetic duplications in phage lambda. IV. The locations of spontaneously arising tandem duplications

Scott W. Emmons, John O. Thomas

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Twenty-four spontaneously arising, long DNA addition derivatives of phage lambda have been isolated by two methods (one physical, one genetic) based on phage DNA content. All are shown to contain a tandem duplication of phage DNA by a number of criteria. The location of the duplicated segment in each has been determined by electron microscopy of DNA hereroduplexes. The duplications are found to lie at random throughout the chromosome, with no preferential locations for endpoints. This rules out the possibility that duplications are formed by crossing-over at regions of homology on the phage chromosome.

Original languageEnglish (US)
Pages (from-to)147-152
Number of pages6
JournalJournal of Molecular Biology
Issue number2
Publication statusPublished - Jan 15 1975
Externally publishedYes


ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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