Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms

Kritsada Pruksaphon, Joshua D. Nosanchuk, Kavi Ratanabanangkoon, Sirida Youngchim

Research output: Contribution to journalReview articlepeer-review

Abstract

Talaromycosis (Penicilliosis) is an opportunistic mycosis caused by the thermally dimor-phic fungus Talaromyces (Penicillium) marneffei. Similar to other major causes of systemic mycoses, the extent of disease and outcomes are the results of complex interactions between this opportunistic human pathogen and a host’s immune response. This review will highlight the current knowledge regarding the dynamic interaction between T. marneffei and mammalian hosts, particularly highlighting important aspects of virulence factors, intracellular lifestyle and the mechanisms of immune defense as well as the strategies of the pathogen for manipulating and evading host immune cells.

Original languageEnglish (US)
Article number200
JournalJournal of Fungi
Volume8
Issue number2
DOIs
StatePublished - Feb 2022

Keywords

  • Acquired immunity
  • Immune es-cape
  • Immune response
  • Innate immunity
  • Macrophages
  • Talaromyces marneffei
  • Virulence factors

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Plant Science
  • Microbiology (medical)

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