Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms

Kritsada Pruksaphon; Joshua D. Nosanchuk; Kavi Ratanabanangkoon; Sirida Youngchim

doi:10.3390/jof8020200

Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms

Kritsada Pruksaphon, Joshua D. Nosanchuk, Kavi Ratanabanangkoon, Sirida Youngchim

Medicine

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Talaromycosis (Penicilliosis) is an opportunistic mycosis caused by the thermally dimor-phic fungus Talaromyces (Penicillium) marneffei. Similar to other major causes of systemic mycoses, the extent of disease and outcomes are the results of complex interactions between this opportunistic human pathogen and a host’s immune response. This review will highlight the current knowledge regarding the dynamic interaction between T. marneffei and mammalian hosts, particularly highlighting important aspects of virulence factors, intracellular lifestyle and the mechanisms of immune defense as well as the strategies of the pathogen for manipulating and evading host immune cells.

Original language	English (US)
Article number	200
Journal	Journal of Fungi
Volume	8
Issue number	2
DOIs	https://doi.org/10.3390/jof8020200
State	Published - Feb 2022

Keywords

Acquired immunity
Immune es-cape
Immune response
Innate immunity
Macrophages
Talaromyces marneffei
Virulence factors

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Plant Science
Microbiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/jof8020200

Cite this

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title = "Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms",

abstract = "Talaromycosis (Penicilliosis) is an opportunistic mycosis caused by the thermally dimor-phic fungus Talaromyces (Penicillium) marneffei. Similar to other major causes of systemic mycoses, the extent of disease and outcomes are the results of complex interactions between this opportunistic human pathogen and a host{\textquoteright}s immune response. This review will highlight the current knowledge regarding the dynamic interaction between T. marneffei and mammalian hosts, particularly highlighting important aspects of virulence factors, intracellular lifestyle and the mechanisms of immune defense as well as the strategies of the pathogen for manipulating and evading host immune cells.",

keywords = "Acquired immunity, Immune es-cape, Immune response, Innate immunity, Macrophages, Talaromyces marneffei, Virulence factors",

author = "Kritsada Pruksaphon and Nosanchuk, {Joshua D.} and Kavi Ratanabanangkoon and Sirida Youngchim",

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language = "English (US)",

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journal = "Journal of Fungi",

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AU - Pruksaphon, Kritsada

AU - Nosanchuk, Joshua D.

AU - Ratanabanangkoon, Kavi

AU - Youngchim, Sirida

PY - 2022/2

Y1 - 2022/2

N2 - Talaromycosis (Penicilliosis) is an opportunistic mycosis caused by the thermally dimor-phic fungus Talaromyces (Penicillium) marneffei. Similar to other major causes of systemic mycoses, the extent of disease and outcomes are the results of complex interactions between this opportunistic human pathogen and a host’s immune response. This review will highlight the current knowledge regarding the dynamic interaction between T. marneffei and mammalian hosts, particularly highlighting important aspects of virulence factors, intracellular lifestyle and the mechanisms of immune defense as well as the strategies of the pathogen for manipulating and evading host immune cells.

AB - Talaromycosis (Penicilliosis) is an opportunistic mycosis caused by the thermally dimor-phic fungus Talaromyces (Penicillium) marneffei. Similar to other major causes of systemic mycoses, the extent of disease and outcomes are the results of complex interactions between this opportunistic human pathogen and a host’s immune response. This review will highlight the current knowledge regarding the dynamic interaction between T. marneffei and mammalian hosts, particularly highlighting important aspects of virulence factors, intracellular lifestyle and the mechanisms of immune defense as well as the strategies of the pathogen for manipulating and evading host immune cells.

KW - Acquired immunity

KW - Immune es-cape

KW - Immune response

KW - Innate immunity

KW - Macrophages

KW - Talaromyces marneffei

KW - Virulence factors

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DO - 10.3390/jof8020200

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Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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