TY - JOUR
T1 - Takotsubo cardiomyopathy
T2 - Evidence from observational studies and pathophysiology
AU - Santoro, Francesco
AU - Brunetti, Natale Daniele
AU - Tarantino, Nicola
AU - Ieva, Riccardo
AU - Di Biase, Matteo
AU - Di Biase, Luigi
PY - 2016/10
Y1 - 2016/10
N2 - Takotsubo cardiomyopathy is an acute reversible form of cardiac failure, firstly described in 1991, with a prognosis not favorable as previously thought. Although high levels of catecholamines have been suggested as the leading mechanism for the onset, the pathophysiology remains unclear. However, several pathophysiological explanations have been proposed, all not mutually exclusive. A complex chain of events is present, including the activation of the hypothalamic-pituitary-Adrenal axis, the surge in circulating catecholamines and subsequent cardiovascular responses. This review addresses the diagnostic classification, short and mid-Term prognosis, precipitating factors, classification into primary and secondary forms, and possible drug therapies for stress cardiomyopathy. Clinical and experimental studies are needed to further improve diagnosis and targeted therapies.
AB - Takotsubo cardiomyopathy is an acute reversible form of cardiac failure, firstly described in 1991, with a prognosis not favorable as previously thought. Although high levels of catecholamines have been suggested as the leading mechanism for the onset, the pathophysiology remains unclear. However, several pathophysiological explanations have been proposed, all not mutually exclusive. A complex chain of events is present, including the activation of the hypothalamic-pituitary-Adrenal axis, the surge in circulating catecholamines and subsequent cardiovascular responses. This review addresses the diagnostic classification, short and mid-Term prognosis, precipitating factors, classification into primary and secondary forms, and possible drug therapies for stress cardiomyopathy. Clinical and experimental studies are needed to further improve diagnosis and targeted therapies.
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M3 - Review article
C2 - 27869898
AN - SCOPUS:84994388456
SN - 1827-6806
VL - 17
SP - 806
EP - 815
JO - Giornale Italiano di Cardiologia
JF - Giornale Italiano di Cardiologia
IS - 10
ER -