Taking control of castleman disease: Leveraging precision medicine technologies to accelerate rare disease research

Samantha Kass Newman, Raj K. Jayanthan, Grant W. Mitchell, Jossie A. Carreras Tartak, Michael P. Croglio, Alexander Suarez, Amy Y. Liu, Beatrice M. Razzo, Enny Oyeniran, Jason R. Ruth, David C. Fajgenbaum

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Castleman disease (CD†) is a rare and heterogeneous disorder characterized by lymphadenopathy that may occur in a single lymph node (unicentric) or multiple lymph nodes (multicentric), the latter typically occurring secondary to excessive proinflammatory hypercytokinemia. While a cohort of multicentric Castleman disease (MCD) cases are caused by Human Herpes Virus-8 (HHV-8), the etiology of HHV-8 negative, idiopathic MCD (iMCD), remains unknown. Breakthroughs in “omics” technologies that have facilitated the development of precision medicine hold promise for elucidating disease pathogenesis and identifying novel therapies for iMCD. However, in order to leverage precision medicine approaches in rare diseases like CD, stakeholders need to overcome several challenges. To address these challenges, the Castleman Disease Collaborative Network (CDCN) was founded in 2012. In the past 3 years, the CDCN has worked to transform the understanding of the pathogenesis of CD, funded and initiated genomics and proteomics research, and united international experts in a collaborative effort to accelerate progress for CD patients. The CDCN’s collaborative structure leverages the tools of precision medicine and serves as a model for both scientific discovery and advancing patient care.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalYale Journal of Biology and Medicine
Volume88
Issue number4
StatePublished - Dec 2015
Externally publishedYes

Keywords

  • Castleman disease
  • Genomics
  • Interleukin-6
  • Lymphoproliferative disorder
  • Orphan disease
  • Precision medicine
  • Rare disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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