Tackling EGFR signaling with TACE antagonists: A rational target for metalloprotease inhibitors in cancer

Paraic A. Kenny

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

TNF-α converting enzyme (TACE/ADAM17) is a transmembrane metalloprotease that plays a key role in the cleavage and mobilization of receptor ligands that are initially synthesized as membrane-tethered precursors. For many years, attention has focused on the role of TACE-dependent TNF-α cleavage in arthritis and, more recently, it has become apparent that TACE also plays an important role in regulating epidermal growth factor receptor activity in several tumor types. This review presents the background to these findings and a rationale for the continued development of TACE inhibitors for the treatment of epidermal growth factor receptor-dependent epithelial tumors.

Original languageEnglish (US)
Pages (from-to)1287-1298
Number of pages12
JournalExpert Opinion on Therapeutic Targets
Volume11
Issue number10
DOIs
StatePublished - Oct 1 2007

Keywords

  • ADAM17
  • Cancer
  • EGFR
  • Metalloprotease inhibitor
  • Sheddase

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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