TACE: A new target in epidermal growth factor receptor dependent tumors

Paraic A. Kenny

Research output: Contribution to journalReview article

56 Scopus citations

Abstract

Soluble proteins play vital roles in mediating intercellular communication. Many of these proteins are secreted as freely soluble molecules, but an important class of signaling proteins are first synthesized and presented at the cell surface as transmembrane precursor proteins. Unlike classically secreted proteins, many of these molecules are regulated at an additional level, requiring proteolytic cleavage for activity. This review focuses on a subset of these proteins, which are cleaved by tumor necrosis factor alpha-converting enzyme (TACE)/ADAM17, and on their role in cancer.

Original languageEnglish (US)
Pages (from-to)800-808
Number of pages9
JournalDifferentiation
Volume75
Issue number9
DOIs
Publication statusPublished - Nov 2007

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Keywords

  • Breast cancer
  • Cancer therapy
  • EGFR
  • Metalloproteinases
  • TACE

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology
  • Cancer Research

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