TACE: A new target in epidermal growth factor receptor dependent tumors

Paraic A. Kenny

doi:10.1111/j.1432-0436.2007.00198.x

TACE: A new target in epidermal growth factor receptor dependent tumors

Paraic A. Kenny

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Abstract

Soluble proteins play vital roles in mediating intercellular communication. Many of these proteins are secreted as freely soluble molecules, but an important class of signaling proteins are first synthesized and presented at the cell surface as transmembrane precursor proteins. Unlike classically secreted proteins, many of these molecules are regulated at an additional level, requiring proteolytic cleavage for activity. This review focuses on a subset of these proteins, which are cleaved by tumor necrosis factor alpha-converting enzyme (TACE)/ADAM17, and on their role in cancer.

Original language	English (US)
Pages (from-to)	800-808
Number of pages	9
Journal	Differentiation
Volume	75
Issue number	9
DOIs	https://doi.org/10.1111/j.1432-0436.2007.00198.x
State	Published - Nov 2007
Externally published	Yes

Keywords

Breast cancer
Cancer therapy
EGFR
Metalloproteinases
TACE

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1432-0436.2007.00198.x

Cite this

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title = "TACE: A new target in epidermal growth factor receptor dependent tumors",

abstract = "Soluble proteins play vital roles in mediating intercellular communication. Many of these proteins are secreted as freely soluble molecules, but an important class of signaling proteins are first synthesized and presented at the cell surface as transmembrane precursor proteins. Unlike classically secreted proteins, many of these molecules are regulated at an additional level, requiring proteolytic cleavage for activity. This review focuses on a subset of these proteins, which are cleaved by tumor necrosis factor alpha-converting enzyme (TACE)/ADAM17, and on their role in cancer.",

keywords = "Breast cancer, Cancer therapy, EGFR, Metalloproteinases, TACE",

author = "Kenny, {Paraic A.}",

note = "Funding Information: Acknowledgments The work described in this review was performed in the laboratory of Mina J. Bissell and was supported by grants and a Distinguished Fellowship Award from the U.S. Department of Energy, Office of Biological and Environmental Research (DE-AC03 SF0098), and in part by National Cancer Institute (2 R01 CA064786-09), and an Innovator Award from the Department of Defense Breast Cancer Research Program (BC012005) to M. J. B.; P. A. K. was supported by fellowships from Susan G. Komen Breast Cancer Foundation (#2000-223) and DOD BCRP (DAMD17-00-1-0224).",

year = "2007",

month = nov,

doi = "10.1111/j.1432-0436.2007.00198.x",

language = "English (US)",

volume = "75",

pages = "800--808",

journal = "Differentiation",

issn = "0301-4681",

publisher = "Elsevier BV",

number = "9",

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T2 - A new target in epidermal growth factor receptor dependent tumors

AU - Kenny, Paraic A.

N1 - Funding Information: Acknowledgments The work described in this review was performed in the laboratory of Mina J. Bissell and was supported by grants and a Distinguished Fellowship Award from the U.S. Department of Energy, Office of Biological and Environmental Research (DE-AC03 SF0098), and in part by National Cancer Institute (2 R01 CA064786-09), and an Innovator Award from the Department of Defense Breast Cancer Research Program (BC012005) to M. J. B.; P. A. K. was supported by fellowships from Susan G. Komen Breast Cancer Foundation (#2000-223) and DOD BCRP (DAMD17-00-1-0224).

PY - 2007/11

Y1 - 2007/11

N2 - Soluble proteins play vital roles in mediating intercellular communication. Many of these proteins are secreted as freely soluble molecules, but an important class of signaling proteins are first synthesized and presented at the cell surface as transmembrane precursor proteins. Unlike classically secreted proteins, many of these molecules are regulated at an additional level, requiring proteolytic cleavage for activity. This review focuses on a subset of these proteins, which are cleaved by tumor necrosis factor alpha-converting enzyme (TACE)/ADAM17, and on their role in cancer.

AB - Soluble proteins play vital roles in mediating intercellular communication. Many of these proteins are secreted as freely soluble molecules, but an important class of signaling proteins are first synthesized and presented at the cell surface as transmembrane precursor proteins. Unlike classically secreted proteins, many of these molecules are regulated at an additional level, requiring proteolytic cleavage for activity. This review focuses on a subset of these proteins, which are cleaved by tumor necrosis factor alpha-converting enzyme (TACE)/ADAM17, and on their role in cancer.

KW - Breast cancer

KW - Cancer therapy

KW - EGFR

KW - Metalloproteinases

KW - TACE

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DO - 10.1111/j.1432-0436.2007.00198.x

M3 - Review article

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AN - SCOPUS:36048938454

SN - 0301-4681

VL - 75

SP - 800

EP - 808

JO - Differentiation

JF - Differentiation

IS - 9

ER -

TACE: A new target in epidermal growth factor receptor dependent tumors

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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