T-regulatory cells in lymph nodes

Julián Arce, Miles Levin, Qingmei Xie, Joseph Albanese, Howard Ratech

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Because T-regulatory cells (Tregs) can harmfully impair HIV-specific responses or beneficially limit immune activation, we compared the number of Tregs in lymph nodes from 48 HIV+ patients and 106 HIV-subjects. By using a microscope counting grid, we found that the mean ± SD number of Tregs in lymph nodes was 3 times greater in HIV+ males than HIV+ females (23.5 ± 20.7 vs 7.8 ± 7.7; P = .0006) and almost twice as great in HIV+ males than HIV- males (23.5 ± 20.7 vs 13.5 ± 15.5; P = .04). There were fewer Tregs in HIV+ females than in HIV- females (mean ± SD, 7.8 ± 7.7 vs 13.4 ± 13.3; P = .04). HIV+ males compared with HIV+ females had higher viral loads (VLs) and lower peripheral blood (PB) CD4 cell counts (mean ± SD, 239,841 ± 307,494 vs 73,038 ± 146,763 copies/mL and 262 ± 207 vs 466 ± 278/mm3; P = .02 and P = .01, respectively). Our data show that Tregs in lymph nodes from HIV+ patients are positively correlated with VL and negatively correlated with PB CD4 counts. These findings suggest that Tregs might impair an HIV-specific immune response, which could be modified by sex, or, alternatively, an increased VL causes increased Tregs.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume136
Issue number1
DOIs
StatePublished - Jul 2011

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Regulatory T-Lymphocytes
Lymph Nodes
HIV
Viral Load
CD4 Lymphocyte Count
Blood Cell Count

Keywords

  • FOXP3
  • HIV
  • Human herpesvirus 8
  • LAG-3
  • T-regulatory cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Arce, J., Levin, M., Xie, Q., Albanese, J., & Ratech, H. (2011). T-regulatory cells in lymph nodes. American Journal of Clinical Pathology, 136(1), 35-42. https://doi.org/10.1309/AJCPAR39BFWNHWRO

T-regulatory cells in lymph nodes. / Arce, Julián; Levin, Miles; Xie, Qingmei; Albanese, Joseph; Ratech, Howard.

In: American Journal of Clinical Pathology, Vol. 136, No. 1, 07.2011, p. 35-42.

Research output: Contribution to journalArticle

Arce, J, Levin, M, Xie, Q, Albanese, J & Ratech, H 2011, 'T-regulatory cells in lymph nodes', American Journal of Clinical Pathology, vol. 136, no. 1, pp. 35-42. https://doi.org/10.1309/AJCPAR39BFWNHWRO
Arce, Julián ; Levin, Miles ; Xie, Qingmei ; Albanese, Joseph ; Ratech, Howard. / T-regulatory cells in lymph nodes. In: American Journal of Clinical Pathology. 2011 ; Vol. 136, No. 1. pp. 35-42.
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