T lymphocyte abnormalities in juvenile systemic sclerosis patients

Andreas Reiff, Kenneth I. Weinberg, Timothy Triche, Bernadette Masinsin, Kris M. Mahadeo, Chuan Hao Lin, Diane Brown, Robertson Parkman

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Multi-center evaluations of pediatric patients with juvenile systemic sclerosis (jSSc) have suggested that the pathogenesis of jSSc may differ from that of systemic sclerosis (SSc) in adult patients. Therefore, we undertook to identify abnormalities in the T lymphocytes of jSSc patients and to determine if they differed from the abnormalities reported in the T lymphocytes of adult SSc patients. We identified decreases in the frequency of resting regulatory T lymphocytes and an increased frequency of CD45RA expressing effector memory (EMRA) CD4 T lymphocytes, which were characterized by an increased frequency of CCR7 protein expressing cells. Neither the increases in the EMRA subpopulation nor the increased CCR7 protein expression have been reported in adult SSc patients. The decrease in resting regulatory T lymphocytes in jSSc patients may permit the expansion of the disease initiating CD4 T lymphocytes present in the CCR7 expressing EMRA CD4 T lymphocyte subpopulation.

Original languageEnglish (US)
Pages (from-to)146-155
Number of pages10
JournalClinical Immunology
Volume149
Issue number1
DOIs
StatePublished - Oct 1 2013

Keywords

  • Autoreactive T lymphocytes
  • CCR7;
  • Juvenile systemic sclerosis;
  • Regulatory T lymphocytes;

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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