T-cell recognition of non-peptide antigens

Steven A. Porcelli, Craig T. Morita, Robert L. Modlin

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Studies of two distinct human T-cell systems have provided the exciting finding that T cells are able to recognize non-peptide antigens: γδ T cells have been shown to recognize isopentenyl pyrophosphate and related structures and human CD1 has been shown to present microbial lipids and lipoglycans such as mycolic acids and lipoarabinomannan to T cells. T-cell responses to these non-peptide antigens should provide a strategic target for immunologic intervention in infectious disease.

Original languageEnglish (US)
Pages (from-to)510-516
Number of pages7
JournalCurrent Opinion in Immunology
Volume8
Issue number4
DOIs
StatePublished - Aug 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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