T-cell receptor specificity of CD8+ Tregs in allotransplantation

Elodie Picarda, Ignacio Anegon, Carole Guillonneau

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Recent studies in the field of CD8+ Tregs have allowed a better identification and characterization of this subset of regulatory cells. Their key role in the regulation of allogeneic responses is now well established. To take full advantage of CD8+ Treg cells in future therapeutic applications, a better knowledge is required, particularly concerning the contribution of the T-cell receptor (TCR) in cell function as well as the role and importance of its antigenic specificity. Here, we focused on the CD8 +CD45RClow Tregs, which in rats induce an indefinite long-term allograft acceptance. We summarized recent findings on their interaction properties with antigen-presenting cells. Identification of the antigenic targets and TCR repertoire of CD8+ Tregs will allow a better understanding of their recognition properties and will highlight the potential of such of specific population in cell-based treatment.

Original languageEnglish (US)
Pages (from-to)35-37
Number of pages3
JournalImmunotherapy
Volume3
Issue number4 SUPPL.
DOIs
StatePublished - Apr 2011
Externally publishedYes

Keywords

  • antigen specificity
  • CD8 regulatory T cells
  • TCR
  • tolerance
  • transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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