T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis

Jeffrey M. Critchfield, Michael K. Racke, Juan Carlos Zúñiga-Rlücker, Barbara Cannella, Cedric S. Raine, Joan Goverman, Michael J. Lenardo

Research output: Contribution to journalArticle

480 Citations (Scopus)

Abstract

Encounters with antigen can stimulate T cells to become activated and proliferate, become nonresponsive to antigen, or to die. T cell death was shown to be a physiological response to interleukin-2-stimulated cell cycling and T cell receptor reengagement at high antigen doses. This feedback regulatory mechanism attenuates the immune response by deleting a portion of newly dividing, antigen-reactive T cells. This mechanism deleted autoreactive T cells and abrogated the clinical and pathological signs of autoimmune encephalomyelitis in mice after repetitive administration of myelin basic protein.

Original languageEnglish (US)
Pages (from-to)1139-1143
Number of pages5
JournalScience
Volume263
Issue number5150
StatePublished - Feb 25 1994

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Encephalomyelitis
T-Lymphocytes
Antigens
Myelin Basic Protein
Therapeutics
T-Cell Antigen Receptor
Interleukin-2
Cell Death

ASJC Scopus subject areas

  • General

Cite this

Critchfield, J. M., Racke, M. K., Zúñiga-Rlücker, J. C., Cannella, B., Raine, C. S., Goverman, J., & Lenardo, M. J. (1994). T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science, 263(5150), 1139-1143.

T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. / Critchfield, Jeffrey M.; Racke, Michael K.; Zúñiga-Rlücker, Juan Carlos; Cannella, Barbara; Raine, Cedric S.; Goverman, Joan; Lenardo, Michael J.

In: Science, Vol. 263, No. 5150, 25.02.1994, p. 1139-1143.

Research output: Contribution to journalArticle

Critchfield, JM, Racke, MK, Zúñiga-Rlücker, JC, Cannella, B, Raine, CS, Goverman, J & Lenardo, MJ 1994, 'T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis', Science, vol. 263, no. 5150, pp. 1139-1143.
Critchfield JM, Racke MK, Zúñiga-Rlücker JC, Cannella B, Raine CS, Goverman J et al. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science. 1994 Feb 25;263(5150):1139-1143.
Critchfield, Jeffrey M. ; Racke, Michael K. ; Zúñiga-Rlücker, Juan Carlos ; Cannella, Barbara ; Raine, Cedric S. ; Goverman, Joan ; Lenardo, Michael J. / T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. In: Science. 1994 ; Vol. 263, No. 5150. pp. 1139-1143.
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